If you’ve ever wondered what your brain and body are doing during those hours you spend unconscious each night, you’re asking the right question. To truly optimise your sleep, or even just to make informed decisions about it, understanding sleep architecture is remarkably helpful. Sleep architecture is essentially the pattern of sleep as measured by sophisticated equipment, but in more practical terms, it’s the rhythm and depth of your sleep across the night. This pattern serves as a useful proxy for sleep quality, and it’s one of the more accessible windows we have into what’s actually happening while you’re asleep.

The reason understanding sleep architecture matters is twofold. First, it’s something we can actually measure with reasonable accuracy these days, even with consumer devices. Second, when sleep architecture looks good, we can reasonably assume that most of the other restorative processes happening during sleep are also proceeding as they should. It’s not a perfect correlation, and there are certainly cases where architecture appears normal but other issues lurk beneath, but generally speaking, things that disrupt the body’s restorative processes during sleep will also leave their fingerprints on your sleep architecture.

You see, while sleeping feels like you’ve been switched off, like powering down a laptop, sleep is actually a remarkably active process. Your brain doesn’t simply idle in neutral for eight hours. Throughout the night, intricate processes unfold; memories consolidate, tissues repair, hormones release, waste products clear from your brain, and your immune system recalibrates. We can observe some of this activity by measuring brain waves, but we could also track body temperature, blood pressure, blood glucose levels, and yes, even the number of times your genitals become engorged during the night (nocturnal penile tumescence, often called “morning wood,” or nocturnal clitoral tumescence, sometimes called “morning bean”). These physiological changes tell us that sleep is anything but passive.

Now, truly accurate sleep architecture measurement isn’t straightforward. You’d need to visit a specialised sleep laboratory, get wired up with electrodes across your scalp and body, and undergo polysomnography (e.g. a proper sleep study). However, the proliferation of wearable devices has democratised sleep tracking to some extent. While these consumer devices can’t match the precision of laboratory polysomnography, many provide a “good enough” approximation of your sleep architecture to be genuinely useful.

But what does good sleep architecture actually look like? To answer that, we need to understand the stages of sleep themselves.

Measuring Sleep: From Laboratory to Your Wrist

Before diving into the stages, it’s worth briefly understanding how we measure sleep in the first place. Polysomnography (the gold standard for sleep measurement) simultaneously tracks multiple physiological signals: brain waves (via electroencephalography or EEG), eye movements (electrooculography), muscle tone (electromyography), heart rate, breathing patterns, and oxygen levels. This comprehensive monitoring allows sleep specialists to identify not just which stage of sleep you’re in, but also to spot disorders like sleep apnoea, restless legs syndrome, or periodic limb movement disorder.

Sleep studies are typically recommended when there’s suspicion of a sleep disorder that’s causing daytime impairment, such as chronic snoring with gasping, unexplained excessive daytime sleepiness, violent movements during sleep, or other concerning symptoms. For most people, however, a full sleep study isn’t necessary.

Consumer wearables have become increasingly sophisticated, though it’s important to understand their limitations. Most rely on actigraphy (measuring movement) combined with heart rate data to infer sleep stages. Some newer devices incorporate more advanced sensors that approximate EEG measurements. These devices are generally quite good at determining when you’re asleep versus awake, reasonably accurate for identifying REM sleep (due to its distinctive physiological signature), but less reliable at distinguishing between the different stages of non-REM sleep. They’re useful for tracking trends and patterns in your own sleep over time, but the specific numbers (“you got 87 minutes of deep sleep”) should be taken with a grain of salt. What matters more is the overall pattern and how it changes in response to your behaviours.

Sleep questionnaires and subjective assessments also have their place. How you feel upon waking, your daytime energy levels, your ability to concentrate, etc, these subjective measures often matter more than the objective numbers. You can have textbook-perfect sleep architecture on paper but still feel dreadful if something else is amiss, or conversely, have somewhat disrupted architecture but feel well-rested if the disruptions aren’t impairing the sleep’s restorative functions.

sleep architecture

The Stages of Sleep: A Journey Through the Night

Most people have heard that sleep has various stages, and it’s these stages that comprise what we mean by sleep architecture. These stages can be differentiated primarily by measuring brain waves and neuronal activity. There are two very distinct categories of sleep: rapid eye movement (REM) sleep and non-REM sleep. Non-REM sleep is further divided into three stages (though some researchers argue for four distinct stages, the standard classification uses three).

While there’s a clear distinction between REM and non-REM sleep, it’s more useful to think of them as parts of a single “block” or cycle of sleep. One complete cycle encompasses the progression from the start of non-REM sleep through to REM sleep and back to the beginning of the next non-REM period. You complete several of these cycles each night, with the exact number depending on your total sleep duration.

To truly get a grasp on sleep architecture, it helps to walk through exactly what happens when you drift off to sleep and progress through the night.

From Wakefulness to Sleep: The Transition

When you’re falling asleep (perhaps lying in bed with your eyes feeling heavy), you enter stage 1 non-REM sleep. This transition from wakefulness to light sleep lasts only a few minutes. You’ve likely experienced being startled awake during this stage by a sudden noise, and you have that peculiar hazy memory of having been on the cusp of sleep. During stage 1, your heart rate and breathing begin to slow, eye movements reduce, and your muscles relax. You might experience sudden muscle twitches called hypnic jerks, which are those involuntary jolts that sometimes accompany the sensation of falling. Your brain waves slow from the beta waves of active wakefulness into a more relaxed alpha pattern, then into the even slower theta waves.

Stage 1 is brief and forms only a small percentage of your total sleep. You’ll cycle through it multiple times during the night, though after the initial transition into sleep, subsequent passages through stage 1 are usually even shorter.

Stage 2: Where Sleep Really Begins

After a few minutes in stage 1, you transition into stage 2 non-REM sleep. This is where sleep truly begins. It’s still considered light sleep, but it’s notably deeper than stage 1, and waking someone during this stage requires a bit more effort. Someone roused from stage 2 will likely feel they were genuinely asleep, rather than merely drifting in and out of consciousness as they might have felt during stage 1.

During stage 2, your heart rate continues to drop, as does your body temperature. Eye movements cease entirely. This is where you really start seeing the whole-body effects of sleep, as metabolism slows down in response to reduced cellular activity. Brain waves become slower and larger than in stage 1, punctuated by two distinctive features: sleep spindles and K-complexes.

Sleep spindles are brief bursts of rapid brain wave activity that last a second or two. K-complexes are single, large waves that stand out against the background activity. Both appear to play roles in memory consolidation and in protecting sleep from external disturbances. An initial stage 2 period typically lasts around 20 minutes before transitioning to deeper sleep, though across the entire night, you’ll actually spend a substantial portion of your total sleep time in stage 2 (often around 45-55% of the night).

Stage 2 is frequently overlooked in discussions about sleep, which tend to focus on deep sleep and REM sleep. But stage 2 matters considerably. Research suggests it plays important roles in memory consolidation, particularly for motor skills and procedural learning. It’s also during stage 2 that your body continues many of the restorative processes begun in deeper sleep stages.

Stage 3: Deep Sleep and Restoration

Stage 3 non-REM sleep, often called deep sleep or slow-wave sleep, is what most people think of when they imagine restorative sleep. You typically enter stage 3 about 35-45 minutes after initially falling asleep, and you spend more time in this stage during the first half of the night. As the night progresses, subsequent cycles include less stage 3 sleep, with later cycles sometimes bypassing it entirely.

Now, you may be asking, “why does deep sleep concentrate in the early night?” Well, you need to think of it like charging a battery. Initially, the battery needs substantial charging. Once it’s mostly full, later charging sessions only need to top it up. Similarly, your body’s restorative needs are greatest early in the night, and as those needs are met, less time in deep sleep is required in later cycles.

However, this pattern isn’t rigid. Individuals engaged in demanding physical training may notice their deep sleep remains robust throughout the night, as their bodies simply have greater repair demands. These individuals often need more total sleep as well, which is why athletes are generally advised to sleep more than sedentary individuals.

Stage 3 was previously divided into stage 3 and stage 4 in older classification systems, but most current research treats this as a single stage, despite some internal variation in depth. During deep sleep, your heartbeat and breathing slow to their lowest rates of the night. Your muscles relax even further, and blood supply to your muscles increases. Your brain waves transition into large, slow delta waves. These are the slowest and largest waves of any sleep stage.

The outside world becomes almost completely blocked out during deep sleep. Waking someone from this stage is genuinely difficult, and if you succeed, they’ll likely feel groggy and disoriented (a state called sleep inertia that can last several minutes). Interestingly, it’s also during stage 3 that certain parasomnias occur: sleepwalking, sleep talking, and night terrors (different from nightmares, which occur during REM sleep). People experiencing these parasomnias can appear more awake than they actually are, moving about or speaking while remaining deeply asleep.

What makes deep sleep so crucial is that this is when the most intensive restoration happens. Growth hormone releases during deep sleep, facilitating tissue growth and repair. Your immune system function strengthens, which is why poor sleep makes you more susceptible to illness. Metabolic restoration occurs. Perhaps most fascinatingly, the brain’s glymphatic system (essentially the brain’s waste clearance system) becomes much more active during deep sleep. This system clears out metabolic waste products that accumulate during waking hours, including proteins like beta-amyloid that are implicated in neurodegenerative diseases.

Deep sleep also plays a vital role in memory consolidation, particularly for declarative memories (facts, events, and knowledge you can consciously recall). The slow oscillations of deep sleep appear to help transfer memories from temporary storage in the hippocampus to more permanent storage in the cortex.

For anyone interested in health and fitness, maximising deep sleep is clearly important. But, and this is crucial, we can’t selectively optimise for one stage while neglecting others. All stages serve essential purposes, and your body will naturally allocate time to each according to its needs.

stages of sleep

REM Sleep: Active Sleep and Sense-Making

You first enter REM sleep roughly 90 minutes after falling asleep, following your initial progression through the non-REM stages. As the night continues, the relationship between stage 3 and REM sleep essentially inverts: you spend progressively more time in REM and less in deep sleep. By the final sleep cycles of the night, you’re primarily alternating between stage 2 and REM, with little or no stage 3.

REM sleep is the easiest stage to identify visually because of those rapid eye movements darting beneath closed eyelids. But other changes are equally dramatic. Breathing becomes faster and irregular, contrasting sharply with the slow, steady breathing of deep sleep. Heart rate and blood pressure rise, often reaching levels similar to waking. Body temperature regulation becomes more variable, and you’re essentially less able to regulate your temperature during REM, which is one reason bedroom temperature matters for sleep quality.

Most remarkably, your muscles (except those controlling breathing, heartbeat, and eye movements) are effectively paralysed during REM sleep. This temporary muscle atonia is important because your brain activity during REM sleep closely resembles waking activity. You’re dreaming, and without this protective paralysis, you’d physically act out those dreams. The rapid eye movements themselves are hypothesised to correspond to the visual aspects of dreams, as your eyes track the imagery your brain is generating.

This muscle inhibition is a carefully orchestrated neurological phenomenon, but like any complex system, it can occasionally misfire. Sometimes you regain mental consciousness before physical control returns, resulting in sleep paralysis (a frightening experience where you’re awake and aware but temporarily unable to move). This often occurs during the semi-dream state, so people experiencing sleep paralysis frequently report hallucinations or sensing a malevolent presence. At the other extreme, the muscle inhibition can fail to engage properly, leading to REM sleep behaviour disorder, where people do act out their dreams, sometimes violently. Sleepwalking during REM is particularly dangerous too, and surprisingly common.

This muscle inhibition also intersects with other bodily functions in occasionally problematic ways. The signals inhibiting muscle movement can sometimes override the signals controlling bladder function, particularly in children whose nervous systems are still developing this coordination. This contributes to bedwetting, often accompanied by dreams about urinating. Adults who’ve had too much alcohol can experience similar issues, as alcohol disrupts the precise coordination of these inhibitory signals.

Now, you may be wondering, “what’s actually happening in your brain during REM sleep?” Well, activity concentrates in areas involved in storing memories, learning, and emotional regulation, although stage 3 is also crucial for these functions. Most dreaming occurs during REM sleep, and this dreaming may be part of how your brain interprets, processes, and consolidates the day’s experiences, both factual and emotional.

I think of REM sleep as your “sense-making” time. It’s when you make sense of the world, integrating new information with existing knowledge, processing emotional experiences, and consolidating both procedural and emotional memories. This is why ideas, solutions, inventions, musical compositions, or stories sometimes arrive fully formed in dreams. You’re not conjuring something from nothing, you’re synthesising information you’ve already gathered, making new connections, seeing patterns you missed while awake.

This sense-making function is why inadequate REM sleep has such pronounced cognitive and emotional consequences. People deprived of REM sleep struggle with memory formation, decision-making, emotional regulation, and creative problem-solving. After periods of REM deprivation, your brain exhibits “REM rebound”, which is where you spend extra time in REM sleep to compensate for what was missed.

It’s worth emphasising that while REM sleep has distinctive functions, all sleep stages work together. Memory consolidation, learning, and emotional regulation don’t happen exclusively in one stage. REM sleep performs its sense-making and consolidation against the backdrop of the restoration and initial processing that occurred during non-REM sleep.

sleep stages

The Architecture of the Night: How Cycles Progress

Understanding sleep architecture means understanding not just individual stages but how they fit together across the night. Sleep progresses in a stepwise manner, but not in the simple linear fashion often described.

After falling asleep and moving through stages 1, 2, and 3, you reach your first REM period. This initial REM period is usually quite brief, perhaps only 10 minutes. Then, rather than jumping straight back to stage 1, you descend stepwise back toward deep sleep: from REM to stage 2, potentially briefly into stage 3, then back up through stage 2 to REM again. This creates a wave-like pattern when graphed, with sleep depth rising and falling throughout the night.

Each complete cycle (from one REM period to the next) lasts roughly 80-120 minutes. This is often simplified to “90-minute sleep cycles,” but that’s an approximation. The actual duration varies between individuals, varies across the night (later cycles tend to be slightly longer), and varies depending on what you did while awake. If you’ve been in a hyper-stimulating novel environment while also engaging in strenuous physical activity, your sleep architecture will differ from a day spent at home doing familiar, sedentary activities.

These cycles do become somewhat entrained to your daily rhythm, particularly if you maintain consistent sleep and wake times. But they’re not rigid, and individual variation is considerable.

As the night progresses, the composition of each cycle shifts dramatically. Your first cycle might include 20-30 minutes of deep sleep and only 10 minutes of REM. By your final cycle, you might have no deep sleep at all, spending 30-40 minutes in REM with the remainder in stage 2. This shifting architecture reflects changing physiological priorities: restoration and repair dominate early night, while memory consolidation and emotional processing dominate the later hours.

You typically complete 4-6 complete cycles per night, depending on your total sleep duration. Brief awakenings occur between cycles, usually so brief you don’t remember them in the morning. These micro-awakenings are completely normal and don’t indicate fragmented or poor-quality sleep, though if something causes you to fully wake during these transition points, falling back asleep can sometimes take a few minutes.

sleep architecture

Variations in Sleep Architecture: Individual Differences and External Factors

Now, it is important to realise that sleep architecture isn’t static across your lifetime, and it varies considerably between individuals. Understanding these variations helps contextualise your own sleep patterns and adjust expectations appropriately.

Age produces some of the most dramatic changes. Infants and young children spend far more time in REM sleep, sometimes 50% of their sleep, compared to 20-25% in adults. They also have shorter sleep cycles, around 50-60 minutes rather than 90. Deep sleep is also more abundant in childhood and adolescence, supporting the intensive growth and development occurring during these years.

As you age, deep sleep typically decreases. Many elderly individuals get very little stage 3 sleep, spending most of the night alternating between stage 2 and REM. However, elderly individuals who remain cognitively active and engaged in mentally demanding activities often maintain more robust REM sleep. Physical activity also helps preserve sleep architecture quality in older adults. The decline in deep sleep with age isn’t inevitable or necessarily problematic; it may simply reflect reduced restorative demands rather than impaired sleep.

Sex differences exist as well, though they’re less dramatic than age-related changes. Women typically get slightly more deep sleep than men and may have different responses to sleep disruption. Hormonal fluctuations across the menstrual cycle can affect sleep architecture, as can pregnancy and menopause.

Your daily activities acutely affect that night’s sleep architecture. Intense physical training increases deep sleep duration, as your body has greater repair demands. Cognitively demanding days (like when learning a new skill, navigating unfamiliar environments, or doing intense mental work) can increase REM sleep as your brain processes and consolidates that information. Stressful days often fragment sleep architecture, with more frequent awakenings and less time in deep sleep, as your heightened arousal system interferes with the descent into deep sleep stages.

Various substances dramatically alter sleep architecture, almost always detrimentally. Alcohol is particularly notorious for this, and while it might help you fall asleep initially, it suppresses REM sleep in the first half of the night and fragments sleep in the second half as it metabolises. You’ll often get a REM rebound in early morning, which is why dreams can be vivid and disturbing after drinking. The result is sleep that looks adequate in duration but is poor in quality. Caffeine, even consumed hours before bed, can reduce deep sleep and overall sleep efficiency. Cannabis affects sleep architecture in complex ways that aren’t fully understood, but chronic use appears to suppress REM sleep and can make sleep more fragmented.

Sleep disorders disrupt architecture in characteristic patterns. Sleep apnoea fragments sleep with repeated brief awakenings, preventing progression into deeper stages. Restless legs syndrome and periodic limb movement disorder cause arousals that similarly prevent deep, consolidated sleep. These disruptions show up clearly in polysomnography and are one reason sleep studies are valuable when disorders are suspected.

Even your sleep environment affects architecture. Noise, light, temperature extremes, etc., can prevent descent into deep sleep or cause arousals that fragment your cycles. This is why sleep hygiene emphasises controlling these environmental factors.

Perhaps most dramatically, sleep deprivation causes acute changes in architecture. After sleep loss, you’ll experience a deep sleep rebound; spending more time in stage 3 to catch up on that restorative sleep. This is one reason why “catching up” on sleep after a poor night does help, even though it can’t fully compensate for the lost sleep.

Ultimately, not all sleep hours are equal. You could spend eight hours in bed but wake feeling unrefreshed if your sleep architecture was fragmented or disrupted. Fragmented sleep (frequent awakenings or arousals that prevent you from completing full cycles) is qualitatively different from consolidated sleep of the same duration. You might accumulate eight hours on paper, but if you’re constantly cycling back to stage 1 rather than descending into deep sleep, you’re missing the restorative benefits.

This distinction between quantity and quality is crucial for understanding sleep architecture. Sleep efficiency (the percentage of time in bed actually spent asleep) provides one measure of this. Normal sleep efficiency is 85% or higher. If you’re in bed for eight hours but only sleeping for six, that 75% sleep efficiency suggests something is preventing consolidated sleep, even if those six hours include normal stage progression.

What “good architecture” enables is the complete suite of restorative processes: physical repair and growth, immune system strengthening, metabolic regulation, waste clearance from the brain, memory consolidation, emotional processing, and creative integration. Disrupted architecture, even with adequate duration, impairs these processes. You’ll feel the effects as grogginess, difficulty concentrating, emotional irritability, reduced physical performance, and often, weakened immunity.

The consequences compound over time. Chronic disruption of sleep architecture, whether from sleep disorders, lifestyle factors, or environmental issues, doesn’t just make you tired. It increases risks for cardiovascular disease, metabolic disorders, cognitive decline, and mental health problems. This isn’t about catastrophising sleep imperfections; occasional disrupted nights are part of normal human life. But patterns of fragmented or shortened sleep that consistently prevent normal architecture from unfolding do have meaningful health consequences.

Using This Knowledge Practically

So what should you do with this understanding of sleep architecture? First, recognise what you can and cannot control. You cannot directly manipulate which sleep stages you enter or how long you spend in each. Your brain handles that automatically based on your physiological needs. What you can control are the conditions that allow normal architecture to unfold naturally: allowing for adequate sleep duration (i.e. getting to bed on time), consistent timing, appropriate sleep environment, avoiding substances that disrupt sleep, and addressing any underlying sleep disorders.

If you’re using a sleep tracker, now you have context for interpreting the data. You don’t need to obsess over hitting perfect numbers each night; there’s too much normal variation for that to be useful. Instead, look for patterns over weeks. Are you consistently getting very little deep sleep? That might indicate you’re not allowing enough total sleep time, since deep sleep concentrates early in the night and gets cut off if you wake too soon. Are you getting very little REM? You might be cutting sleep short in the morning hours when REM predominates. Seeing fragmented architecture with frequent awakenings? Consider environmental factors, stress, substances, or potential sleep disorders.

The practical knowledge that sleep cycles last roughly 90 minutes can inform wake-up timing. Waking at the end of a cycle, during REM or stage 2, will leave you feeling more alert than waking from deep sleep. If you have flexibility in wake time, targeting intervals that align with 90-minute cycles (6 hours, 7.5 hours, 9 hours) might help you wake more easily. But this shouldn’t become rigid—individual variation means your cycles might be 80 or 110 minutes, and quality matters more than precise timing.

Understanding that deep sleep dominates early night while REM dominates late night has implications too. If you must curtail sleep, losing the first hours is worse than losing the final hours, as you’d miss the concentrated deep sleep. Conversely, sleeping in occasionally gives you extra REM sleep, which supports the cognitive and emotional benefits you might miss when consistently sleeping shorter durations.

Most importantly, understanding sleep architecture should reduce anxiety about sleep. You now know that brief awakenings between cycles are normal. You know that architecture changes with age, activity, and circumstances. You know that while all stages matter, your body is quite good at prioritising what it needs most. This knowledge helps you focus on what actually matters: getting adequate sleep duration in a good environment on a consistent schedule, rather than obsessing over optimising specific stages you can’t directly control.

Understanding Sleep Architecture Conclusion: The Symphony of Sleep

Understanding sleep architecture reveals sleep to be far more than time spent unconscious. It’s a carefully orchestrated progression through distinct states, each serving essential functions, all working together to restore your body and mind. You descend from light sleep into the deep restoration of slow-wave sleep, then rise into the active sense-making of REM sleep, cycling through this pattern multiple times each night with shifting emphasis as different needs are met.

The architecture changes across your lifetime, adapts to your daily activities, and responds to your health and environment. It’s both remarkably resilient (your brain will generally get what it needs if you give it adequate opportunity), and somewhat fragile, disrupted by substances, disorders, stress, and poor sleep practices.

Unfortunately, you cannot hack sleep stages or selectively optimise individual components. But you can optimise the conditions that allow your natural sleep architecture to unfold as it should: sufficient time, consistent timing, good environment, healthy habits, and addressing any disorders that fragment sleep. When you do this, your sleep architecture takes care of itself, providing the restoration, consolidation, and sense-making that enable you to think clearly, feel emotionally balanced, perform physically, and maintain your health.

Sleep is foundational. It’s not the purpose of life, but it provides the physical and mental capacity to engage fully with what matters to you. Understanding sleep architecture doesn’t just satisfy curiosity; it empowers you to make informed choices that protect this foundation, ensuring you have the energy, clarity, and resilience to live vigorously and well.

As with everything, there is always more to learn, and we haven’t even begun to scratch the surface with all this stuff. However, if you are interested in staying up to date with all our content, we recommend subscribing to our newsletter and bookmarking our free content page. We do have a lot of content on sleep in our sleep hub.

If you would like more help with your training (or nutrition), we do also have online coaching spaces available.

We also recommend reading our foundational nutrition articles, along with our foundational articles on exercise and stress management, if you really want to learn more about how to optimise your lifestyle. If you want even more free information on sleep, you can follow us on Instagram, YouTube or listen to the podcast, where we discuss all the little intricacies of exercise.

Finally, if you want to learn how to coach nutrition, then consider our Nutrition Coach Certification course. We do also have an exercise program design course, if you are a coach who wants to learn more about effective program design and how to coach it. We do have other courses available too, notably as a sleep course. If you don’t understand something, or you just need clarification, you can always reach out to us on Instagram or via email.

References and Further Reading

Vyazovskiy, V. (2015). Sleep, recovery, and metaregulation: explaining the benefits of sleep. Nature and Science of Sleep, 171. http://doi.org/10.2147/nss.s54036

Sharma, S., & Kavuru, M. (2010). Sleep and Metabolism: An Overview. International Journal of Endocrinology, 2010, 1–12. http://doi.org/10.1155/2010/270832

Yoo, S.-S., Gujar, N., Hu, P., Jolesz, F. A., & Walker, M. P. (2007). The human emotional brain without sleep — a prefrontal amygdala disconnect. Current Biology, 17(20). http://doi.org/10.1016/j.cub.2007.08.007

Copinschi G. Metabolic and endocrine effects of sleep deprivation. Essent Psychopharmacol. 2005;6(6):341-7. PMID: 16459757. https://pubmed.ncbi.nlm.nih.gov/16459757/

Spiegel, K., Leproult, R., L’Hermite-Balériaux, M., Copinschi, G., Penev, P. D., & Cauter, E. V. (2004). Leptin Levels Are Dependent on Sleep Duration: Relationships with Sympathovagal Balance, Carbohydrate Regulation, Cortisol, and Thyrotropin. The Journal of Clinical Endocrinology & Metabolism, 89(11), 5762–5771. http://doi.org/10.1210/jc.2004-1003

Nedeltcheva, A. V., Kilkus, J. M., Imperial, J., Kasza, K., Schoeller, D. A., & Penev, P. D. (2008). Sleep curtailment is accompanied by increased intake of calories from snacks. The American Journal of Clinical Nutrition, 89(1), 126–133. http://doi.org/10.3945/ajcn.2008.26574

Mullington, J. M., Chan, J. L., Dongen, H. P. A. V., Szuba, M. P., Samaras, J., Price, N. J., … Mantzoros, C. S. (2003). Sleep Loss Reduces Diurnal Rhythm Amplitude of Leptin in Healthy Men. Journal of Neuroendocrinology, 15(9), 851–854. http://doi.org/10.1046/j.1365-2826.2003.01069.x

Leproult, R., & Cauter, E. V. (2009). Role of Sleep and Sleep Loss in Hormonal Release and Metabolism. Pediatric Neuroendocrinology Endocrine Development, 11–21. http://doi.org/10.1159/000262524

Spaeth, A. M., Dinges, D. F., & Goel, N. (2013). Effects of Experimental Sleep Restriction on Weight Gain, Caloric Intake, and Meal Timing in Healthy Adults. Sleep, 36(7), 981–990. http://doi.org/10.5665/sleep.2792

Calvin, A. D., Carter, R. E., Adachi, T., Macedo, P. G., Albuquerque, F. N., Walt, C. V. D., … Somers, V. K. (2013). Effects of Experimental Sleep Restriction on Caloric Intake and Activity Energy Expenditure. Chest, 144(1), 79–86. http://doi.org/10.1378/chest.12-2829

Markwald, R. R., Melanson, E. L., Smith, M. R., Higgins, J., Perreault, L., Eckel, R. H., & Wright, K. P. (2013). Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain. Proceedings of the National Academy of Sciences, 110(14), 5695–5700. http://doi.org/10.1073/pnas.1216951110

Cauter, E. V., Spiegel, K., Tasali, E., & Leproult, R. (2008). Metabolic consequences of sleep and sleep loss. Sleep Medicine, 9. http://doi.org/10.1016/s1389-9457(08)70013-3

Spiegel, K., Leproult, R., & Cauter, E. V. (1999). Impact of sleep debt on metabolic and endocrine function. The Lancet, 354(9188), 1435–1439. http://doi.org/10.1016/s0140-6736(99)01376-8

Ness, K. M., Strayer, S. M., Nahmod, N. G., Schade, M. M., Chang, A.-M., Shearer, G. C., & Buxton, O. M. (2019). Four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety. Journal of Lipid Research, 60(11), 1935–1945. http://doi.org/10.1194/jlr.p094375

Hirotsu, C., Tufik, S., & Andersen, M. L. (2015). Interactions between sleep, stress, and metabolism: From physiological to pathological conditions. Sleep Science, 8(3), 143–152. http://doi.org/10.1016/j.slsci.2015.09.002

Morselli, L., Leproult, R., Balbo, M., & Spiegel, K. (2010). Role of sleep duration in the regulation of glucose metabolism and appetite. Best Practice & Research Clinical Endocrinology & Metabolism, 24(5), 687–702. http://doi.org/10.1016/j.beem.2010.07.005

Lamon, S., Morabito, A., Arentson-Lantz, E., Knowles, O., Vincent, G. E., Condo, D., … Aisbett, B. (2020). The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment. http://doi.org/10.1101/2020.03.09.984666

Lipton, J. O., & Sahin, M. (2014). The Neurology of mTOR. Neuron, 84(2), 275–291. http://doi.org/10.1016/j.neuron.2014.09.034

Tudor, J. C., Davis, E. J., Peixoto, L., Wimmer, M. E., Tilborg, E. V., Park, A. J., … Abel, T. (2016). Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis. Science Signaling, 9(425). http://doi.org/10.1126/scisignal.aad4949

Dattilo, M., Antunes, H., Medeiros, A., Neto, M. M., Souza, H., Tufik, S., & Mello, M. D. (2011). Sleep and muscle recovery: Endocrinological and molecular basis for a new and promising hypothesis. Medical Hypotheses, 77(2), 220–222. http://doi.org/10.1016/j.mehy.2011.04.017

Thornton, S. N., & Trabalon, M. (2014). Chronic dehydration is associated with obstructive sleep apnoea syndrome. Clinical Science, 128(3), 225–225. http://doi.org/10.1042/cs20140496

Rosinger, A. Y., Chang, A.-M., Buxton, O. M., Li, J., Wu, S., & Gao, X. (2018). Short sleep duration is associated with inadequate hydration: cross-cultural evidence from US and Chinese adults. Sleep, 42(2). http://doi.org/10.1093/sleep/zsy210

Watson, A. M. (2017). Sleep and Athletic Performance. Current Sports Medicine Reports, 16(6), 413–418. http://doi.org/10.1249/jsr.0000000000000418

Bonnar, D., Bartel, K., Kakoschke, N., & Lang, C. (2018). Sleep Interventions Designed to Improve Athletic Performance and Recovery: A Systematic Review of Current Approaches. Sports Medicine, 48(3), 683–703. http://doi.org/10.1007/s40279-017-0832-x

Saidi, O., Davenne, D., Lehorgne, C., & Duché, P. (2020). Effects of timing of moderate exercise in the evening on sleep and subsequent dietary intake in lean, young, healthy adults: randomized crossover study. European Journal of Applied Physiology, 120(7), 1551–1562. http://doi.org/10.1007/s00421-020-04386-6

Abedelmalek, S., Chtourou, H., Aloui, A., Aouichaoui, C., Souissi, N., & Tabka, Z. (2012). Effect of time of day and partial sleep deprivation on plasma concentrations of IL-6 during a short-term maximal performance. European Journal of Applied Physiology, 113(1), 241–248. http://doi.org/10.1007/s00421-012-2432-7

Azboy, O., & Kaygisiz, Z. (2009). Effects of sleep deprivation on cardiorespiratory functions of the runners and volleyball players during rest and exercise. Acta Physiologica Hungarica, 96(1), 29–36. http://doi.org/10.1556/aphysiol.96.2009.1.3

Bird, S. P. (2013). Sleep, Recovery, and Athletic Performance. Strength and Conditioning Journal, 35(5), 43–47. http://doi.org/10.1519/ssc.0b013e3182a62e2f

Blumert, P. A., Crum, A. J., Ernsting, M., Volek, J. S., Hollander, D. B., Haff, E. E., & Haff, G. G. (2007). The Acute Effects of Twenty-Four Hours of Sleep Loss on the Performance of National-Caliber Male Collegiate Weightlifters. The Journal of Strength and Conditioning Research, 21(4), 1146. http://doi.org/10.1519/r-21606.1

Chase, J. D., Roberson, P. A., Saunders, M. J., Hargens, T. A., Womack, C. J., & Luden, N. D. (2017). One night of sleep restriction following heavy exercise impairs 3-km cycling time-trial performance in the morning. Applied Physiology, Nutrition, and Metabolism, 42(9), 909–915. http://doi.org/10.1139/apnm-2016-0698

Edwards, B. J., & Waterhouse, J. (2009). Effects of One Night of Partial Sleep Deprivation upon Diurnal Rhythms of Accuracy and Consistency in Throwing Darts. Chronobiology International, 26(4), 756–768. http://doi.org/10.1080/07420520902929037

Fullagar, H. H. K., Skorski, S., Duffield, R., Hammes, D., Coutts, A. J., & Meyer, T. (2014). Sleep and Athletic Performance: The Effects of Sleep Loss on Exercise Performance, and Physiological and Cognitive Responses to Exercise. Sports Medicine, 45(2), 161–186. http://doi.org/10.1007/s40279-014-0260-0

Gupta, L., Morgan, K., & Gilchrist, S. (2016). Does Elite Sport Degrade Sleep Quality? A Systematic Review. Sports Medicine, 47(7), 1317–1333. http://doi.org/10.1007/s40279-016-0650-6

Hausswirth, C., Louis, J., Aubry, A., Bonnet, G., Duffield, R., & Meur, Y. L. (2014). Evidence of Disturbed Sleep and Increased Illness in Overreached Endurance Athletes. Medicine & Science in Sports & Exercise, 46(5), 1036–1045. http://doi.org/10.1249/mss.0000000000000177

Mah, C. D., Mah, K. E., Kezirian, E. J., & Dement, W. C. (2011). The Effects of Sleep Extension on the Athletic Performance of Collegiate Basketball Players. Sleep, 34(7), 943–950. http://doi.org/10.5665/sleep.1132

Milewski, M. D., Skaggs, D. L., Bishop, G. A., Pace, J. L., Ibrahim, D. A., Wren, T. A., & Barzdukas, A. (2014). Chronic Lack of Sleep is Associated With Increased Sports Injuries in Adolescent Athletes. Journal of Pediatric Orthopaedics, 34(2), 129–133. http://doi.org/10.1097/bpo.0000000000000151

Mougin, F., Bourdin, H., Simon-Rigaud, M., Didier, J., Toubin, G., & Kantelip, J. (1996). Effects of a Selective Sleep Deprivation on Subsequent Anaerobic Performance. International Journal of Sports Medicine, 17(02), 115–119. http://doi.org/10.1055/s-2007-972818

Oliver, S. J., Costa, R. J. S., Laing, S. J., Bilzon, J. L. J., & Walsh, N. P. (2009). One night of sleep deprivation decreases treadmill endurance performance. European Journal of Applied Physiology, 107(2), 155–161. http://doi.org/10.1007/s00421-009-1103-9

Pallesen, S., Gundersen, H. S., Kristoffersen, M., Bjorvatn, B., Thun, E., & Harris, A. (2017). The Effects of Sleep Deprivation on Soccer Skills. Perceptual and Motor Skills, 124(4), 812–829. http://doi.org/10.1177/0031512517707412

Reilly, T., & Piercy, M. (1994). The effect of partial sleep deprivation on weight-lifting performance. Ergonomics, 37(1), 107–115. http://doi.org/10.1080/00140139408963628

Rossa, K. R., Smith, S. S., Allan, A. C., & Sullivan, K. A. (2014). The Effects of Sleep Restriction on Executive Inhibitory Control and Affect in Young Adults. Journal of Adolescent Health, 55(2), 287–292. http://doi.org/10.1016/j.jadohealth.2013.12.034

Sargent, C., & Roach, G. D. (2016). Sleep duration is reduced in elite athletes following night-time competition. Chronobiology International, 33(6), 667–670. http://doi.org/10.3109/07420528.2016.1167715

Skein, M., Duffield, R., Edge, J., Short, M. J., & Mündel, T. (2011). Intermittent-Sprint Performance and Muscle Glycogen after 30 h of Sleep Deprivation. Medicine & Science in Sports & Exercise, 43(7), 1301–1311. http://doi.org/10.1249/mss.0b013e31820abc5a

Souissi, N., Sesboüé, B., Gauthier, A., Larue, J., & Davenne, D. (2003). Effects of one nights sleep deprivation on anaerobic performance the following day. European Journal of Applied Physiology, 89(3), 359–366. http://doi.org/10.1007/s00421-003-0793-7

Caia, J., Kelly, V. G., & Halson, S. L. (2017). The role of sleep in maximising performance in elite athletes. Sport, Recovery, and Performance, 151–167. http://doi.org/10.4324/9781315268149-11

Alley, J. R., Mazzochi, J. W., Smith, C. J., Morris, D. M., & Collier, S. R. (2015). Effects of Resistance Exercise Timing on Sleep Architecture and Nocturnal Blood Pressure. Journal of Strength and Conditioning Research, 29(5), 1378–1385. http://doi.org/10.1519/jsc.0000000000000750

Kovacevic, A., Mavros, Y., Heisz, J. J., & Singh, M. A. F. (2018). The effect of resistance exercise on sleep: A systematic review of randomized controlled trials. Sleep Medicine Reviews, 39, 52–68. http://doi.org/10.1016/j.smrv.2017.07.002

Herrick, J. E., Puri, S., & Richards, K. C. (2017). Resistance training does not alter same-day sleep architecture in institutionalized older adults. Journal of Sleep Research, 27(4). http://doi.org/10.1111/jsr.12590

Edinger, J. D., Morey, M. C., Sullivan, R. J., Higginbotham, M. B., Marsh, G. R., Dailey, D. S., & McCall, W. V. (1993). Aerobic fitness, acute exercise and sleep in older men. Sleep, 16(4), 351-359. https://doi.org/10.1093/sleep/16.4.351

King, A. C. (1997). Moderate-intensity exercise and self-rated quality of sleep in older adults. A randomized controlled trial. JAMA: The Journal of the American Medical Association, 277(1), 32–37. http://doi.org/10.1001/jama.277.1.32

Passos, G. S., Poyares, D., Santana, M. G., Garbuio, S. A., Tufik, S., & Mello, M. T. (2010). Effect of Acute Physical Exercise on Patients with Chronic Primary Insomnia. Journal of Clinical Sleep Medicine, 06(03), 270–275. http://doi.org/10.5664/jcsm.27825

Reid, K. J., Baron, K. G., Lu, B., Naylor, E., Wolfe, L., & Zee, P. C. (2010). Aerobic exercise improves self-reported sleep and quality of life in older adults with insomnia. Sleep Medicine, 11(9), 934–940. http://doi.org/10.1016/j.sleep.2010.04.014

Viana, V. A. R., Esteves, A. M., Boscolo, R. A., Grassmann, V., Santana, M. G., Tufik, S., & Mello, M. T. D. (2011). The effects of a session of resistance training on sleep patterns in the elderly. European Journal of Applied Physiology, 112(7), 2403–2408. http://doi.org/10.1007/s00421-011-2219-2

Herring, M., Kline, C., & Oconnor, P. (2015). Effects of Exercise Training On Self-reported Sleep Among Young Women with Generalized Anxiety Disorder (GAD). European Psychiatry, 30, 465. http://doi.org/10.1016/s0924-9338(15)31893-9

Kredlow, M. A., Capozzoli, M. C., Hearon, B. A., Calkins, A. W., & Otto, M. W. (2015). The effects of physical activity on sleep: a meta-analytic review. Journal of Behavioral Medicine, 38(3), 427–449. http://doi.org/10.1007/s10865-015-9617-6

Yang, P.-Y., Ho, K.-H., Chen, H.-C., & Chien, M.-Y. (2012). Exercise training improves sleep quality in middle-aged and older adults with sleep problems: a systematic review. Journal of Physiotherapy, 58(3), 157–163. http://doi.org/10.1016/s1836-9553(12)70106-6

Kline, C. E., Sui, X., Hall, M. H., Youngstedt, S. D., Blair, S. N., Earnest, C. P., & Church, T. S. (2012). Dose–response effects of exercise training on the subjective sleep quality of postmenopausal women: exploratory analyses of a randomised controlled trial. BMJ Open, 2(4). http://doi.org/10.1136/bmjopen-2012-001044

Fairbrother, K., Cartner, B. W., Triplett, N., Morris, D. M., & Collier, S. R. (2011). The Effects of Aerobic Exercise Timing on Sleep Architecture. Medicine & Science in Sports & Exercise, 43(Suppl 1), 879. http://doi.org/10.1249/01.mss.0000402452.16375.20

Youngstedt, S. D., & Kline, C. E. (2006). Epidemiology of exercise and sleep. Sleep and Biological Rhythms, 4(3), 215–221. http://doi.org/10.1111/j.1479-8425.2006.00235.x

Stenholm, S., Head, J., Kivimäki, M., Hanson, L. L. M., Pentti, J., Rod, N. H., … Vahtera, J. (2018). Sleep Duration and Sleep Disturbances as Predictors of Healthy and Chronic Disease–Free Life Expectancy Between Ages 50 and 75: A Pooled Analysis of Three Cohorts. The Journals of Gerontology: Series A, 74(2), 204–210. http://doi.org/10.1093/gerona/gly01

Xiao, Q., Keadle, S. K., Hollenbeck, A. R., & Matthews, C. E. (2014). Sleep Duration and Total and Cause-Specific Mortality in a Large US Cohort: Interrelationships With Physical Activity, Sedentary Behavior, and Body Mass Index. American Journal of Epidemiology, 180(10), 997–1006. http://doi.org/10.1093/aje/kwu222

Reynolds, A. C., Dorrian, J., Liu, P. Y., Dongen, H. P. A. V., Wittert, G. A., Harmer, L. J., & Banks, S. (2012). Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men. PLoS ONE, 7(7). http://doi.org/10.1371/journal.pone.0041218

Åkerstedt, T., Palmblad, J., Torre, B. D. L., Marana, R., & Gillberg, M. (1980). Adrenocortical and Gonadal Steroids During Sleep Deprivation. Sleep, 3(1), 23–30. http://doi.org/10.1093/sleep/3.1.23

Cortés-Gallegos, V., Castañeda, G., Alonso, R., Sojo, I., Carranco, A., Cervantes, C., & Parra, A. (1983). Sleep Deprivation Reduces Circulating Androgens in Healthy Men. Archives of Andrology, 10(1), 33–37. http://doi.org/10.3109/01485018308990167

González-Santos, M. R., Gajá-Rodíguez, O. V., Alonso-Uriarte, R., Sojo-Aranda, I., & Cortés-Gallegos, V. (1989). Sleep Deprivation and Adaptive Hormonal Responses of Healthy Men. Archives of Andrology, 22(3), 203–207. http://doi.org/10.3109/01485018908986773

Penev, P. D. (2007). Association Between Sleep and Morning Testosterone Levels In Older Men. Sleep, 30(4), 427–432. http://doi.org/10.1093/sleep/30.4.427

Kloss, J. D., Perlis, M. L., Zamzow, J. A., Culnan, E. J., & Gracia, C. R. (2015). Sleep, sleep disturbance, and fertility in women. Sleep Medicine Reviews, 22, 78–87. http://doi.org/10.1016/j.smrv.2014.10.005

Mahoney, M. M. (2010). Shift Work, Jet Lag, and Female Reproduction. International Journal of Endocrinology, 2010, 1–9. http://doi.org/10.1155/2010/813764

Labyak, S., Lava, S., Turek, F., & Zee, P. (2002). Effects Of Shiftwork On Sleep And Menstrual Function In Nurses. Health Care for Women International, 23(6-7), 703–714. http://doi.org/10.1080/07399330290107449

Pal, L., Bevilacqua, K., Zeitlian, G., Shu, J., & Santoro, N. (2008). Implications of diminished ovarian reserve (DOR) extend well beyond reproductive concerns. Menopause, 15(6), 1086–1094. http://doi.org/10.1097/gme.0b013e3181728467

Axelsson, G., Rylander, R., & Molin, I. (1989). Outcome of pregnancy in relation to irregular and inconvenient work schedules. Occupational and Environmental Medicine, 46(6), 393–398. http://doi.org/10.1136/oem.46.6.393

Bisanti, L., Olsen, J., Basso, O., Thonneau, P., & Karmaus, W. (1996). Shift Work and Subfecundity: A European Multicenter Study. Journal of Occupational & Environmental Medicine, 38(4), 352–358. http://doi.org/10.1097/00043764-199604000-00012

Rossmanith, W. G. (1998). The impact of sleep on gonadotropin secretion. Gynecological Endocrinology, 12(6), 381–389. http://doi.org/10.3109/09513599809012840

Fernando, S., & Rombauts, L. (2014). Melatonin: shedding light on infertility? – a review of the recent literature. Journal of Ovarian Research, 7(1). http://doi.org/10.1186/s13048-014-0098-y

Rocha, C., Rato, L., Martins, A., Alves, M., & Oliveira, P. (2015). Melatonin and Male Reproductive Health: Relevance of Darkness and Antioxidant Properties. Current Molecular Medicine, 15(4), 299–311. http://doi.org/10.2174/1566524015666150505155530

Song, C., Peng, W., Yin, S., Zhao, J., Fu, B., Zhang, J., … Zhang, Y. (2016). Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice. Scientific Reports, 6(1). http://doi.org/10.1038/srep35165

Espino, J., Macedo, M., Lozano, G., Ortiz, Á., Rodríguez, C., Rodríguez, A. B., & Bejarano, I. (2019). Impact of Melatonin Supplementation in Women with Unexplained Infertility Undergoing Fertility Treatment. Antioxidants, 8(9), 338. http://doi.org/10.3390/antiox8090338

Tamura, H., Takasaki, A., Taketani, T., Tanabe, M., Kizuka, F., Lee, L., … Sugino, N. (2012). The role of melatonin as an antioxidant in the follicle. Journal of Ovarian Research, 5(1), 5. http://doi.org/10.1186/1757-2215-5-5

Saaresranta, T., & Polo, O. (2003). Sleep-disordered breathing and hormones. European Respiratory Journal, 22(1), 161–172. http://doi.org/10.1183/09031936.03.00062403

Cappuccio, F. P., Cooper, D., Delia, L., Strazzullo, P., & Miller, M. A. (2011). Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. European Heart Journal, 32(12), 1484–1492. http://doi.org/10.1093/eurheartj/ehr007

Jansen, E. C., Dunietz, G. L., Tsimpanouli, M.-E., Guyer, H. M., Shannon, C., Hershner, S. D., … Baylin, A. (2018). Sleep, Diet, and Cardiometabolic Health Investigations: a Systematic Review of Analytic Strategies. Current Nutrition Reports, 7(4), 235–258. http://doi.org/10.1007/s13668-018-0240-3

Knutson, K. L., Cauter, E. V., Rathouz, P. J., Yan, L. L., Hulley, S. B., Liu, K., & Lauderdale, D. S. (2009). Association Between Sleep and Blood Pressure in Midlife. Archives of Internal Medicine, 169(11), 1055. http://doi.org/10.1001/archinternmed.2009.119

Besedovsky, L., Lange, T., & Born, J. (2011). Sleep and immune function. Pflügers Archiv – European Journal of Physiology, 463(1), 121–137. http://doi.org/10.1007/s00424-011-1044-0

Besedovsky, L., Lange, T., & Haack, M. (2019). The Sleep-Immune Crosstalk in Health and Disease. Physiological Reviews, 99(3), 1325–1380. http://doi.org/10.1152/physrev.00010.2018

Orr, W. C., Fass, R., Sundaram, S. S., & Scheimann, A. O. (2020). The effect of sleep on gastrointestinal functioning in common digestive diseases. The Lancet Gastroenterology & Hepatology, 5(6), 616–624. http://doi.org/10.1016/s2468-1253(19)30412-1

Tang, Y., Preuss, F., Turek, F. W., Jakate, S., & Keshavarzian, A. (2009). Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis. Sleep Medicine, 10(6), 597–603. http://doi.org/10.1016/j.sleep.2008.12.009

Chen, Y., Tan, F., Wei, L., Li, X., Lyu, Z., Feng, X., … Li, N. (2018). Sleep duration and the risk of cancer: a systematic review and meta-analysis including dose–response relationship. BMC Cancer, 18(1). http://doi.org/10.1186/s12885-018-5025-y

Almendros, I., Martinez-Garcia, M. A., Farré, R., & Gozal, D. (2020). Obesity, sleep apnea, and cancer. International Journal of Obesity, 44(8), 1653–1667. http://doi.org/10.1038/s41366-020-0549-z

Erren, T. C., Falaturi, P., Morfeld, P., Knauth, P., Reiter, R. J., & Piekarski, C. (2010). Shift Work and Cancer. Deutsches Aerzteblatt Online. http://doi.org/10.3238/arztebl.2010.0657

Bernert, R. A., Kim, J. S., Iwata, N. G., & Perlis, M. L. (2015). Sleep Disturbances as an Evidence-Based Suicide Risk Factor. Current Psychiatry Reports, 17(3). http://doi.org/10.1007/s11920-015-0554-4

Kim, J.-H., Park, E.-C., Cho, W.-H., Park, J.-Y., Choi, W.-J., & Chang, H.-S. (2013). Association between Total Sleep Duration and Suicidal Ideation among the Korean General Adult Population. Sleep, 36(10), 1563–1572. http://doi.org/10.5665/sleep.3058

Mccall, W. V., & Black, C. G. (2013). The Link Between Suicide and Insomnia: Theoretical Mechanisms. Current Psychiatry Reports, 15(9). http://doi.org/10.1007/s11920-013-0389-9

Li, S. X., Lam, S. P., Zhang, J., Yu, M. W. M., Chan, J. W. Y., Chan, C. S. Y., … Wing, Y.-K. (2016). Sleep Disturbances and Suicide Risk in an 8-Year Longitudinal Study of Schizophrenia-Spectrum Disorders. Sleep, 39(6), 1275–1282. http://doi.org/10.5665/sleep.5852

Littlewood, D. L., Gooding, P., Kyle, S. D., Pratt, D., & Peters, S. (2016). Understanding the role of sleep in suicide risk: qualitative interview study. BMJ Open, 6(8). http://doi.org/10.1136/bmjopen-2016-012113

Lin, H.-T., Lai, C.-H., Perng, H.-J., Chung, C.-H., Wang, C.-C., Chen, W.-L., & Chien, W.-C. (2018). Insomnia as an independent predictor of suicide attempts: a nationwide population-based retrospective cohort study. BMC Psychiatry, 18(1). http://doi.org/10.1186/s12888-018-1702-2

Freeman, D., Sheaves, B., Waite, F., Harvey, A. G., & Harrison, P. J. (2020). Sleep disturbance and psychiatric disorders. The Lancet Psychiatry, 7(7), 628–637. http://doi.org/10.1016/s2215-0366(20)30136-x

Benca, R. M. (1992). Sleep and Psychiatric Disorders. Archives of General Psychiatry, 49(8), 651. http://doi.org/10.1001/archpsyc.1992.01820080059010

Breslau, N., Roth, T., Rosenthal, L., & Andreski, P. (1996). Sleep disturbance and psychiatric disorders: A longitudinal epidemiological study of young Adults. Biological Psychiatry, 39(6), 411–418. http://doi.org/10.1016/0006-3223(95)00188-3

Baglioni, C., Nanovska, S., Regen, W., Spiegelhalder, K., Feige, B., Nissen, C., … Riemann, D. (2016). Sleep and mental disorders: A meta-analysis of polysomnographic research. Psychological Bulletin, 142(9), 969–990. http://doi.org/10.1037/bul0000053

Goldstein, A. N., & Walker, M. P. (2014). The Role of Sleep in Emotional Brain Function. Annual Review of Clinical Psychology, 10(1), 679–708. http://doi.org/10.1146/annurev-clinpsy-032813-153716

Postuma, R. B., Iranzo, A., Hu, M., Högl, B., Boeve, B. F., Manni, R., … Pelletier, A. (2019). Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. Brain, 142(3), 744–759. http://doi.org/10.1093/brain/awz030

Wintler, T., Schoch, H., Frank, M. G., & Peixoto, L. (2020). Sleep, brain development, and autism spectrum disorders: Insights from animal models. Journal of Neuroscience Research, 98(6), 1137–1149. http://doi.org/10.1002/jnr.24619

Shokri-Kojori, E., Wang, G.-J., Wiers, C. E., Demiral, S. B., Guo, M., Kim, S. W., … Volkow, N. D. (2018). β-Amyloid accumulation in the human brain after one night of sleep deprivation. Proceedings of the National Academy of Sciences, 115(17), 4483–4488. http://doi.org/10.1073/pnas.1721694115

Mantovani, S., Smith, S. S., Gordon, R., & Osullivan, J. D. (2018). An overview of sleep and circadian dysfunction in Parkinsons disease. Journal of Sleep Research, 27(3). http://doi.org/10.1111/jsr.12673

Malhotra, R. K. (2018). Neurodegenerative Disorders and Sleep. Sleep Medicine Clinics, 13(1), 63–70. http://doi.org/10.1016/j.jsmc.2017.09.006

Huang, L.-B., Tsai, M.-C., Chen, C.-Y., & Hsu, S.-C. (2013). The Effectiveness of Light/Dark Exposure to Treat Insomnia in Female Nurses Undertaking Shift Work during the Evening/Night Shift. Journal of Clinical Sleep Medicine, 09(07), 641–646. http://doi.org/10.5664/jcsm.2824

Zhang, Y., & Papantoniou, K. (2019). Night shift work and its carcinogenicity. The Lancet Oncology, 20(10). http://doi.org/10.1016/s1470-2045(19)30578-9

Perry-Jenkins, M., Goldberg, A. E., Pierce, C. P., & Sayer, A. G. (2007). Shift Work, Role Overload, and the Transition to Parenthood. Journal of Marriage and Family, 69(1), 123–138. http://doi.org/10.1111/j.1741-3737.2006.00349.x

Rodziewicz TL, Hipskind JE. Medical Error Prevention. 2020 May 5. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. PMID: 29763131. https://pubmed.ncbi.nlm.nih.gov/29763131/

Tanaka, K., Takahashi, M., Hiro, H., Kakinuma, M., Tanaka, M., Kamata, N., & Miyaoka, H. (2010). Differences in Medical Error Risk among Nurses Working Two- and Three-shift Systems at Teaching Hospitals: A Six-month Prospective Study. Industrial Health, 48(3), 357–364. http://doi.org/10.2486/indhealth.48.357

Admi H, Tzischinsky O, Epstein R, Herer P, Lavie P. Shift work in nursing: is it really a risk factor for nurses’ health and patients’ safety?. Nurs Econ. 2008;26(4):250-257. https://pubmed.ncbi.nlm.nih.gov/18777974/

Clendon, J., & Gibbons, V. (2015). 12h shifts and rates of error among nurses: A systematic review. International Journal of Nursing Studies, 52(7), 1231–1242. http://doi.org/10.1016/j.ijnurstu.2015.03.011

Hammadah, M., Kindya, B. R., Allard‐Ratick, M. P., Jazbeh, S., Eapen, D., Tang, W. W., & Sperling, L. (2017). Navigating air travel and cardiovascular concerns: Is the sky the limit?, Clinical Cardiology, 40 (9), 660–666. http://doi.org/10.1002/clc.22741

Lieber, B. A., Han, J., Appelboom, G., Taylor, B. E., Han, B., Agarwal, N., & Connolly, E. S. (2016). Association of Steroid Use with Deep Venous Thrombosis and Pulmonary Embolism in Neurosurgical Patients: A National Database Analysis. World Neurosurgery, 89, 126–132. http://doi.org/10.1016/j.wneu.2016.01.033

El-Menyar, A., Asim, M., & Al-Thani, H. (2017). Obesity Paradox in Patients With Deep Venous Thrombosis. Clinical and Applied Thrombosis/Hemostasis, 24(6), 986–992. http://doi.org/10.1177/1076029617727858

Klovaite, J., Benn, M., & Nordestgaard, B. G. (2014). Obesity as a causal risk factor for deep venous thrombosis: a Mendelian randomization study. Journal of Internal Medicine, 277(5), 573–584. http://doi.org/10.1111/joim.12299

Davies, H. O., Popplewell, M., Singhal, R., Smith, N., & Bradbury, A. W. (2016). Obesity and lower limb venous disease – The epidemic of phlebesity. Phlebology: The Journal of Venous Disease, 32(4), 227–233. http://doi.org/10.1177/0268355516649333

Liljeqvist, S., Helldén, A., Bergman, U., & Söderberg, M. (2008). Pulmonary embolism associated with the use of anabolic steroids. European Journal of Internal Medicine, 19(3), 214–215. http://doi.org/10.1016/j.ejim.2007.03.016

Linton MF, Yancey PG, Davies SS, Jerome WG (Jay), Linton EF, Vickers KC. The Role of Lipids and Lipoproteins in Atherosclerosis. In: De Groot LJ, Chrousos G, Dungan K, et al., eds. Endotext. South Dartmouth (MA): MDText.com, Inc.; 2000. http://www.ncbi.nlm.nih.gov/books/NBK343489/.

Rescheduling of meals may ease the effects of jet lag. (2017). Nursing Standard, 31(48), 16–16. http://doi.org/10.7748/ns.31.48.16.s17

Ruscitto, C., & Ogden, J. (2016). The impact of an implementation intention to improve mealtimes and reduce jet lag in long-haul cabin crew. Psychology & Health, 32(1), 61–77. http://doi.org/10.1080/08870446.2016.1240174

Reid, K. J., & Abbott, S. M. (2015). Jet Lag and Shift Work Disorder. Sleep Medicine Clinics, 10(4), 523–535. http://doi.org/10.1016/j.jsmc.2015.08.006

Srinivasan, V., Spence, D. W., Pandi-Perumal, S. R., Trakht, I., & Cardinali, D. P. (2008). Jet lag: Therapeutic use of melatonin and possible application of melatonin analogs. Travel Medicine and Infectious Disease, 6(1-2), 17–28. http://doi.org/10.1016/j.tmaid.2007.12.002

Edwards, B. J., Atkinson, G., Waterhouse, J., Reilly, T., Godfrey, R., & Budgett, R. (2000). Use of melatonin in recovery from jet-lag following an eastward flight across 10 time-zones. Ergonomics, 43(10), 1501–1513. http://doi.org/10.1080/001401300750003934

Zee, P. C., & Goldstein, C. A. (2010). Treatment of Shift Work Disorder and Jet Lag. Current Treatment Options in Neurology, 12(5), 396–411. http://doi.org/10.1007/s11940-010-0090-9

https://www.nhlbi.nih.gov/health-topics/circadian-rhythm-disorders

Borodkin, K., & Dagan, Y. (2013). Diagnostic Algorithm for Circadian Rhythm Sleep Disorders. Encyclopedia of Sleep, 66–73. http://doi.org/10.1016/b978-0-12-378610-4.00284-9

Lockley, S. (2013). Special Considerations and Future Directions in Circadian Rhythm Sleep Disorders Diagnosis. Encyclopedia of Sleep, 138–149. http://doi.org/10.1016/b978-0-12-378610-4.00299-0

Crowley, S., & Youngstedt, S. (2013). Pathophysiology, Associations, and Consequences of Circadian Rhythm Sleep Disorder. Encyclopedia of Sleep, 16–21. http://doi.org/10.1016/b978-0-12-378610-4.00266-7

Franken, P., & Dijk, D.-J. (2009). Circadian clock genes and sleep homeostasis. European Journal of Neuroscience, 29(9), 1820–1829. http://doi.org/10.1111/j.1460-9568.2009.06723.x

Burgess, H. J., & Emens, J. S. (2016). Circadian-Based Therapies for Circadian Rhythm Sleep-Wake Disorders. Current Sleep Medicine Reports, 2(3), 158–165. http://doi.org/10.1007/s40675-016-0052-1

Jones, C. R., Huang, A. L., Ptáček, L. J., & Fu, Y.-H. (2013). Genetic basis of human circadian rhythm disorders. Experimental Neurology, 243, 28–33. http://doi.org/10.1016/j.expneurol.2012.07.012

Toh KL. Basic science review on circadian rhythm biology and circadian sleep disorders. Ann Acad Med Singap. 2008;37(8):662-668. https://pubmed.ncbi.nlm.nih.gov/18797559/

Farhud D, Aryan Z. Circadian Rhythm, Lifestyle and Health: A Narrative Review. Iran J Public Health. 2018;47(8):1068-1076. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123576/

Dodson, E. R., & Zee, P. C. (2010). Therapeutics for Circadian Rhythm Sleep Disorders. Sleep Medicine Clinics, 5(4), 701–715. http://doi.org/10.1016/j.jsmc.2010.08.001

Zhu, L., & Zee, P. C. (2012). Circadian Rhythm Sleep Disorders. Neurologic Clinics, 30(4), 1167–1191. http://doi.org/10.1016/j.ncl.2012.08.011

Kim MJ, Lee JH, Duffy JF. Circadian Rhythm Sleep Disorders. J Clin Outcomes Manag. 2013;20(11):513-528. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212693/

Zhong, G., Naismith, S. L., Rogers, N. L., & Lewis, S. J. G. (2011). Sleep-wake disturbances in common neurodegenerative diseases: A closer look at selected aspects of the neural circuitry. Journal of the Neurological Sciences, 307(1-2), 9–14. http://doi.org/10.1016/j.jns.2011.04.020

Dijk, D.-J., Boulos, Z., Eastman, C. I., Lewy, A. J., Campbell, S. S., & Terman, M. (1995). Light Treatment for Sleep Disorders: Consensus Report. Journal of Biological Rhythms, 10(2), 113–125. http://doi.org/10.1177/074873049501000204

Barion, A., & Zee, P. C. (2007). A clinical approach to circadian rhythm sleep disorders. Sleep Medicine, 8(6), 566–577. http://doi.org/10.1016/j.sleep.2006.11.017

Horne JA, Ostberg O. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int J Chronobiol. 1976;4(2):97-110. https://pubmed.ncbi.nlm.nih.gov/1027738/

Adan, A., & Almirall, H. (1991). Horne & Östberg morningness-eveningness questionnaire: A reduced scale. Personality and Individual Differences, 12(3), 241–253. http://doi.org/10.1016/0191-8869(91)90110-w

Urbán, R., Magyaródi, T., & Rigó, A. (2011). Morningness-Eveningness, Chronotypes and Health-Impairing Behaviors in Adolescents. Chronobiology International, 28(3), 238–247. http://doi.org/10.3109/07420528.2010.549599

https://www.thewep.org/documentations/mctq

Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Research, 28(2), 193–213. http://doi.org/10.1016/0165-1781(89)90047-4

Bastien, C. (2001). Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Medicine, 2(4), 297–307. http://doi.org/10.1016/s1389-9457(00)00065-4

Yang, M., Morin, C. M., Schaefer, K., & Wallenstein, G. V. (2009). Interpreting score differences in the Insomnia Severity Index: using health-related outcomes to define the minimally important difference. Current Medical Research and Opinion, 25(10), 2487–2494. http://doi.org/10.1185/03007990903167415

Morin, C. M., Belleville, G., Bélanger, L., & Ivers, H. (2011). The Insomnia Severity Index: Psychometric Indicators to Detect Insomnia Cases and Evaluate Treatment Response. Sleep, 34(5), 601–608. http://doi.org/10.1093/sleep/34.5.601

Castriotta RJ, Wilde MC, Lai JM, Atanasov S, Masel BE, Kuna ST. Prevalence and consequences of sleep disorders in traumatic brain injury. J Clin Sleep Med. 2007;3(4):349-356. https://pubmed.ncbi.nlm.nih.gov/17694722/

Chokroverty S. Overview of sleep & sleep disorders. Indian J Med Res. 2010;131:126-140. https://pubmed.ncbi.nlm.nih.gov/20308738/

Pavlova, M. K., & Latreille, V. (2019). Sleep Disorders. The American Journal of Medicine, 132(3), 292–299. http://doi.org/10.1016/j.amjmed.2018.09.021

Olejniczak, P. W., & Fisch, B. J. (2003). Sleep disorders. Medical Clinics of North America, 87(4), 803–833. http://doi.org/10.1016/s0025-7125(03)00006-3

https://www.nhlbi.nih.gov/health-topics/sleep-apnea

https://clevemed.com/what-is-sleep-apnea/patient-sleep-apnea-screener/

Spicuzza, L., Caruso, D., & Maria, G. D. (2015). Obstructive sleep apnoea syndrome and its management. Therapeutic Advances in Chronic Disease, 6(5), 273–285. http://doi.org/10.1177/2040622315590318

Bixler, E. O., Vgontzas, A. N., Lin, H.-M., Liao, D., Calhoun, S., Fedok, F., … Graff, G. (2008). Blood Pressure Associated With Sleep-Disordered Breathing in a Population Sample of Children. Hypertension, 52(5), 841–846. http://doi.org/10.1161/hypertensionaha.108.116756

Campos, A. I., García-Marín, L. M., Byrne, E. M., Martin, N. G., Cuéllar-Partida, G., & Rentería, M. E. (2020). Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank. Nature Communications, 11(1). http://doi.org/10.1038/s41467-020-14625-1

Morgenthaler, T. I., Kagramanov, V., Hanak, V., & Decker, P. A. (2006). Complex Sleep Apnea Syndrome: Is It a Unique Clinical Syndrome? Sleep, 29(9), 1203–1209. http://doi.org/10.1093/sleep/29.9.1203

El-Ad, B., & Lavie, P. (2005). Effect of sleep apnea on cognition and mood. International Review of Psychiatry, 17(4), 277–282. http://doi.org/10.1080/09540260500104508

Morgenstern, M., Wang, J., Beatty, N., Batemarco, T., Sica, A. L., & Greenberg, H. (2014). Obstructive Sleep Apnea. Endocrinology and Metabolism Clinics of North America, 43(1), 187–204. http://doi.org/10.1016/j.ecl.2013.09.002

Sleep–Related Breathing Disorders in Adults: Recommendations for Syndrome Definition and Measurement Techniques in Clinical Research. (1999). Sleep, 22(5), 667–689. http://doi.org/10.1093/sleep/22.5.667

Ruehland, W. R., Rochford, P. D., O’Donoghue, F. J., Pierce, R. J., Singh, P., & Thornton, A. T. (2009). The New AASM Criteria for Scoring Hypopneas: Impact on the Apnea Hypopnea Index. Sleep, 32(2), 150–157. http://doi.org/10.1093/sleep/32.2.150

Selim, B. J., Koo, B. B., Qin, L., Jeon, S., Won, C., Redeker, N. S., … Yaggi, H. K. (2016). The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal of Clinical Sleep Medicine, 12(06), 829–837. http://doi.org/10.5664/jcsm.5880

Ahmed, M. H. (2010). Obstructive sleep apnea syndrome and fatty liver: Association or causal link? World Journal of Gastroenterology, 16(34), 4243. http://doi.org/10.3748/wjg.v16.i34.4243

Singh, H., Pollock, R., Uhanova, J., Kryger, M., Hawkins, K., & Minuk, G. Y. (2005). Symptoms of Obstructive Sleep Apnea in Patients with Nonalcoholic Fatty Liver Disease. Digestive Diseases and Sciences, 50(12), 2338–2343. http://doi.org/10.1007/s10620-005-3058-y

Lawati, N. M. A., Patel, S. R., & Ayas, N. T. (2009). Epidemiology, Risk Factors, and Consequences of Obstructive Sleep Apnea and Short Sleep Duration. Progress in Cardiovascular Diseases, 51(4), 285–293. http://doi.org/10.1016/j.pcad.2008.08.001

Young, T. (2004). Risk Factors for Obstructive Sleep Apnea in Adults. Jama, 291(16), 2013. http://doi.org/10.1001/jama.291.16.2013

Yaggi, H. K., Concato, J., Kernan, W. N., Lichtman, J. H., Brass, L. M., & Mohsenin, V. (2005). Obstructive Sleep Apnea as a Risk Factor for Stroke and Death. New England Journal of Medicine, 353(19), 2034–2041. http://doi.org/10.1056/nejmoa043104

Redline, S., Budhiraja, R., Kapur, V., Marcus, C. L., Mateika, J. H., Mehra, R., … Quan, A. S. F. (2007). The Scoring of Respiratory Events in Sleep: Reliability and Validity. Journal of Clinical Sleep Medicine, 03(02), 169–200. http://doi.org/10.5664/jcsm.26818

Basheer B, Hegde KS, Bhat SS, Umar D, Baroudi K. Influence of mouth breathing on the dentofacial growth of children: a cephalometric study. J Int Oral Health. 2014;6(6):50-55. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295456/

Ruhle, K. H., & Nilius, G. (2008). Mouth Breathing in Obstructive Sleep Apnea prior to and during Nasal Continuous Positive Airway Pressure. Respiration, 76(1), 40–45. http://doi.org/10.1159/000111806

Izu, S. C., Itamoto, C. H., Pradella-Hallinan, M., Pizarro, G. U., Tufik, S., Pignatari, S., & Fujita, R. R. (2010). Obstructive sleep apnea syndrome (OSAS) in mouth breathing children. Brazilian Journal of Otorhinolaryngology, 76(5), 552–556. http://doi.org/10.1590/s1808-86942010000500003

Lee, S. H., Choi, J. H., Shin, C., Lee, H. M., Kwon, S. Y., & Lee, S. H. (2007). How Does Open-Mouth Breathing Influence Upper Airway Anatomy? The Laryngoscope, 117(6), 1102–1106. http://doi.org/10.1097/mlg.0b013e318042aef7

Tuomilehto, H. P. I., Seppä, J. M., Partinen, M. M., Peltonen, M., Gylling, H., Tuomilehto, J. O. I., … Uusitupa, M. (2009). Lifestyle Intervention with Weight Reduction. American Journal of Respiratory and Critical Care Medicine, 179(4), 320–327. http://doi.org/10.1164/rccm.200805-669oc

https://www.cdc.gov/nchs/fastats/obesity-overweight.htm

Neill, A. M., Angus, S. M., Sajkov, D., & Mcevoy, R. D. (1997). Effects of sleep posture on upper airway stability in patients with obstructive sleep apnea. American Journal of Respiratory and Critical Care Medicine, 155(1), 199–204. http://doi.org/10.1164/ajrccm.155.1.9001312

Loord, H., & Hultcrantz, E. (2007). Positioner–a method for preventing sleep apnea. Acta Oto-Laryngologica, 127(8), 861–868. http://doi.org/10.1080/00016480601089390

Szollosi, I., Roebuck, T., Thompson, B., & Naughton, M. T. (2006). Lateral Sleeping Position Reduces Severity of Central Sleep Apnea / Cheyne-Stokes Respiration. Sleep, 29(8), 1045–1051. http://doi.org/10.1093/sleep/29.8.1045

Silverberg DS, Iaina A, Oksenberg A. Treating obstructive sleep apnea improves essential hypertension and quality of life. Am Fam Physician. 2002;65(2):229-236. https://pubmed.ncbi.nlm.nih.gov/11820487/

Aurora, R. N., Chowdhuri, S., Ramar, K., Bista, S. R., Casey, K. R., Lamm, C. I., … Tracy, S. L. (2012). The Treatment of Central Sleep Apnea Syndromes in Adults: Practice Parameters with an Evidence-Based Literature Review and Meta-Analyses. Sleep, 35(1), 17–40. http://doi.org/10.5665/sleep.1580

Hsu, A. A. L., & Lo, C. (2003). Continuous positive airway pressure therapy in sleep apnoea. Respirology, 8(4), 447–454. http://doi.org/10.1046/j.1440-1843.2003.00494.x

Patel, S. R., White, D. P., Malhotra, A., Stanchina, M. L., & Ayas, N. T. (2003). Continuous Positive Airway Pressure Therapy for Treating gess in a Diverse Population With Obstructive Sleep Apnea. Archives of Internal Medicine, 163(5), 565. http://doi.org/10.1001/archinte.163.5.565

Sundaram, S., Lim, J., & Lasserson, T. J. (2005). Surgery for obstructive sleep apnoea in adults. Cochrane Database of Systematic Reviews. http://doi.org/10.1002/14651858.cd001004.pub2

Chen, H., & Lowe, A. A. (2012). Updates in oral appliance therapy for snoring and obstructive sleep apnea. Sleep and Breathing, 17(2), 473–486. http://doi.org/10.1007/s11325-012-0712-4

Gaisl, T., Haile, S. R., Thiel, S., Osswald, M., & Kohler, M. (2019). Efficacy of pharmacotherapy for OSA in adults: A systematic review and network meta-analysis. Sleep Medicine Reviews, 46, 74–86. http://doi.org/10.1016/j.smrv.2019.04.009

Ohayon, M., Wickwire, E. M., Hirshkowitz, M., Albert, S. M., Avidan, A., Daly, F. J., … Vitiello, M. V. (2017). National Sleep Foundations sleep quality recommendations: first report. Sleep Health, 3(1), 6–19. http://doi.org/10.1016/j.sleh.2016.11.006

Youngstedt, S. D., Goff, E. E., Reynolds, A. M., Kripke, D. F., Irwin, M. R., Bootzin, R. R., … Jean-Louis, G. (2016). Has adult sleep duration declined over the last 50 years? Sleep Medicine Reviews, 28, 69–85. http://doi.org/10.1016/j.smrv.2015.08.004

Chaput, J.-P., Mcneil, J., Després, J.-P., Bouchard, C., & Tremblay, A. (2013). Seven to Eight Hours of Sleep a Night Is Associated with a Lower Prevalence of the Metabolic Syndrome and Reduced Overall Cardiometabolic Risk in Adults. PLoS ONE, 8(9). http://doi.org/10.1371/journal.pone.0072832

Wild, C. J., Nichols, E. S., Battista, M. E., Stojanoski, B., & Owen, A. M. (2018). Dissociable effects of self-reported daily sleep duration on high-level cognitive abilities. Sleep, 41(12). http://doi.org/10.1093/sleep/zsy182

Hirshkowitz, M., Whiton, K., Albert, S. M., Alessi, C., Bruni, O., Doncarlos, L., … Hillard, P. J. A. (2015). National Sleep Foundation’s sleep time duration recommendations: methodology and results summary. Sleep Health, 1(1), 40–43. http://doi.org/10.1016/j.sleh.2014.12.010

Cappuccio, F. P., Delia, L., Strazzullo, P., & Miller, M. A. (2010). Sleep Duration and All-Cause Mortality: A Systematic Review and Meta-Analysis of Prospective Studies. Sleep, 33(5), 585–592. http://doi.org/10.1093/sleep/33.5.585

Gottlieb, D. J., Punjabi, N. M., Newman, A. B., Resnick, H. E., Redline, S., Baldwin, C. M., & Nieto, F. J. (2005). Association of Sleep Time With Diabetes Mellitus and Impaired Glucose Tolerance. Archives of Internal Medicine, 165(8), 863. http://doi.org/10.1001/archinte.165.8.863

Short, M. A., Agostini, A., Lushington, K., & Dorrian, J. (2015). A systematic review of the sleep, sleepiness, and performance implications of limited wake shift work schedules. Scandinavian Journal of Work, Environment & Health, 41(5), 425–440. http://doi.org/10.5271/sjweh.3509

Cappuccio, F. P., Taggart, F. M., Kandala, N.-B., Currie, A., Peile, E., Stranges, S., & Miller, M. A. (2008). Meta-Analysis of Short Sleep Duration and Obesity in Children and Adults. Sleep, 31(5), 619–626. http://doi.org/10.1093/sleep/31.5.619

Mong, J. A., & Cusmano, D. M. (2016). Sex differences in sleep: impact of biological sex and sex steroids. Philosophical Transactions of the Royal Society B: Biological Sciences, 371(1688), 20150110. http://doi.org/10.1098/rstb.2015.0110

Krishnan, V., & Collop, N. A. (2006). Gender differences in sleep disorders. Current Opinion in Pulmonary Medicine, 12(6), 383–389. http://doi.org/10.1097/01.mcp.0000245705.69440.6a

Mehta, N., Shafi, F., & Bhat, A. (2015). Unique Aspects of Sleep in Women. Missouri medicine, 112(6), 430–434. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168103/

Moline, M. L., Broch, L., & Zak, R. (2004). Sleep in women across the life cycle from adulthood through menopause. Medical Clinics of North America, 88(3), 705–736. http://doi.org/10.1016/j.mcna.2004.01.009

He, Y., Jones, C. R., Fujiki, N., Xu, Y., Guo, B., Holder, J. L., … Fu, Y.-H. (2009). The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals. Science, 325(5942), 866–870. http://doi.org/10.1126/science.1174443

Theorell-Haglöw, J., Berglund, L., Berne, C., & Lindberg, E. (2014). Both habitual short sleepers and long sleepers are at greater risk of obesity: a population-based 10-year follow-up in women. Sleep Medicine, 15(10), 1204–1211. http://doi.org/10.1016/j.sleep.2014.02.014

Mezick, E. J., Wing, R. R., & Mccaffery, J. M. (2014). Associations of self-reported and actigraphy-assessed sleep characteristics with body mass index and waist circumference in adults: moderation by gender. Sleep Medicine, 15(1), 64–70. http://doi.org/10.1016/j.sleep.2013.08.784

Kim, S. J. (2011). Relationship Between Weekend Catch-up Sleep and Poor Performance on Attention Tasks in Korean Adolescents. Archives of Pediatrics & Adolescent Medicine, 165(9), 806. http://doi.org/10.1001/archpediatrics.2011.128

Kim, C.-W., Choi, M.-K., Im, H.-J., Kim, O.-H., Lee, H.-J., Song, J., … Park, K.-H. (2012). Weekend catch-up sleep is associated with decreased risk of being overweight among fifth-grade students with short sleep duration. Journal of Sleep Research, 21(5), 546–551. http://doi.org/10.1111/j.1365-2869.2012.01013.x

Sun, W., Ling, J., Zhu, X., Lee, T. M.-C., & Li, S. X. (2019). Associations of weekday-to-weekend sleep differences with academic performance and health-related outcomes in school-age children and youths. Sleep Medicine Reviews, 46, 27–53. http://doi.org/10.1016/j.smrv.2019.04.003

Kang, S.-G., Lee, Y. J., Kim, S. J., Lim, W., Lee, H.-J., Park, Y.-M., … Hong, J. P. (2014). Weekend catch-up sleep is independently associated with suicide attempts and self-injury in Korean adolescents. Comprehensive Psychiatry, 55(2), 319–325. http://doi.org/10.1016/j.comppsych.2013.08.023

Zhao, M., Tuo, H., Wang, S., & Zhao, L. (2020). The Effects of Dietary Nutrition on Sleep and Sleep Disorders. Mediators of Inflammation, 2020, 1–7. http://doi.org/10.1155/2020/3142874

Doherty, Madigan, Warrington, & Ellis. (2019). Sleep and Nutrition Interactions: Implications for Athletes. Nutrients, 11(4), 822. http://doi.org/10.3390/nu11040822

Sutanto CN, Wang MX, Tan D, Kim JE. Association of Sleep Quality and Macronutrient Distribution: A Systematic Review and Meta-Regression. Nutrients. 2020 Jan 2;12(1):126. doi: 10.3390/nu12010126. PMID: 31906452; PMCID: PMC7019667. https://pubmed.ncbi.nlm.nih.gov/31906452/

Peuhkuri, K., Sihvola, N., & Korpela, R. (2012). Diet promotes sleep duration and quality. Nutrition Research, 32(5), 309–319. http://doi.org/10.1016/j.nutres.2012.03.009

Afaghi, A., Oconnor, H., & Chow, C. M. (2007). High-glycemic-index carbohydrate meals shorten sleep onset. The American Journal of Clinical Nutrition, 85(2), 426–430. http://doi.org/10.1093/ajcn/85.2.426

Golem, D. L., Martin-Biggers, J. T., Koenings, M. M., Davis, K. F., & Byrd-Bredbenner, C. (2014). An Integrative Review of Sleep for Nutrition Professionals. Advances in Nutrition, 5(6), 742–759. http://doi.org/10.3945/an.114.006809

Grandner, M. A., Jackson, N., Gerstner, J. R., & Knutson, K. L. (2013). Sleep symptoms associated with intake of specific dietary nutrients. Journal of Sleep Research, 23(1), 22–34. http://doi.org/10.1111/jsr.12084

Porter, J., & Horne, J. (1981). Bed-time food supplements and sleep: Effects of different carbohydrate levels. Electroencephalography and Clinical Neurophysiology, 51(4), 426–433. http://doi.org/10.1016/0013-4694(81)90106-1

Halson, S. L. (2014). Sleep in Elite Athletes and Nutritional Interventions to Enhance Sleep. Sports Medicine, 44(S1), 13–23. http://doi.org/10.1007/s40279-014-0147-0

Rondanelli, M., Opizzi, A., Monteferrario, F., Antoniello, N., Manni, R., & Klersy, C. (2011). The Effect of Melatonin, Magnesium, and Zinc on Primary Insomnia in Long-Term Care Facility Residents in Italy: A Double-Blind, Placebo-Controlled Clinical Trial. Journal of the American Geriatrics Society, 59(1), 82–90. http://doi.org/10.1111/j.1532-5415.2010.03232.x

Tahara, Y., & Shibata, S. (2014). Chrono-biology, Chrono-pharmacology, and Chrono-nutrition. Journal of Pharmacological Sciences, 124(3), 320–335. http://doi.org/10.1254/jphs.13r06cr

Landolt, H.-P., Werth, E., Borbély, A. A., & Dijk, D.-J. (1995). Caffeine intake (200 mg) in the morning affects human sleep and EEG power spectra at night. Brain Research, 675(1-2), 67–74. http://doi.org/10.1016/0006-8993(95)00040-w

Gottesmann, C. (2002). GABA mechanisms and sleep. Neuroscience, 111(2), 231–239. http://doi.org/10.1016/s0306-4522(02)00034-9

Campbell, S. S., Dawson, D., & Anderson, M. W. (1993). Alleviation of Sleep Maintenance Insomnia with Timed Exposure to Bright Light. Journal of the American Geriatrics Society, 41(8), 829–836. http://doi.org/10.1111/j.1532-5415.1993.tb06179.x

Zhao, J., Tian, Y., Nie, J., Xu, J., & Liu, D. (2012). Red Light and the Sleep Quality and Endurance Performance of Chinese Female Basketball Players. Journal of Athletic Training, 47(6), 673–678. http://doi.org/10.4085/1062-6050-47.6.08

Smolensky, M. H., Sackett-Lundeen, L. L., & Portaluppi, F. (2015). Nocturnal light pollution and underexposure to daytime sunlight: Complementary mechanisms of circadian disruption and related diseases. Chronobiology International, 32(8), 1029–1048. http://doi.org/10.3109/07420528.2015.1072002

Düzgün, G., & Akyol, A. D. (2017). Effect of Natural Sunlight on Sleep Problems and Sleep Quality of the Elderly Staying in the Nursing Home. Holistic Nursing Practice, 31(5), 295–302. http://doi.org/10.1097/hnp.0000000000000206

Valham, F., Sahlin, C., Stenlund, H., & Franklin, K. A. (2012). Ambient Temperature and Obstructive Sleep Apnea: Effects on Sleep, Sleep Apnea, and Morning Alertness. Sleep, 35(4), 513–517. http://doi.org/10.5665/sleep.1736

Okamoto-Mizuno, K., Tsuzuki, K., & Mizuno, K. (2004). Effects of mild heat exposure on sleep stages and body temperature in older men. International Journal of Biometeorology, 49(1). http://doi.org/10.1007/s00484-004-0209-3

St-Onge, M.-P., & Shechter, A. (2014). Sleep disturbances, body fat distribution, food intake and/or energy expenditure: pathophysiological aspects. Hormone Molecular Biology and Clinical Investigation, 17(1). http://doi.org/10.1515/hmbci-2013-0066

Chaput, J.-P., Després, J.-P., Bouchard, C., & Tremblay, A. (2008). The Association Between Sleep Duration and Weight Gain in Adults: A 6-Year Prospective Study from the Quebec Family Study. Sleep, 31(4), 517–523. http://doi.org/10.1093/sleep/31.4.517

Dekker, S. A., Noordam, R., Biermasz, N. R., Roos, A., Lamb, H. J., Rosendaal, F. R., … Mutsert, R. (2018). Habitual Sleep Measures are Associated with Overall Body Fat, and not Specifically with Visceral Fat, in Men and Women. Obesity, 26(10), 1651–1658. http://doi.org/10.1002/oby.22289

Tunnicliffe, J. M., Erdman, K. A., Reimer, R. A., Lun, V., & Shearer, J. (2008). Consumption of dietary caffeine and coffee in physically active populations: physiological interactions. Applied Physiology, Nutrition, and Metabolism, 33(6), 1301–1310. http://doi.org/10.1139/h08-124

Mahoney, C. R., Giles, G. E., Marriott, B. P., Judelson, D. A., Glickman, E. L., Geiselman, P. J., & Lieberman, H. R. (2019). Intake of caffeine from all sources and reasons for use by college students. Clinical Nutrition, 38(2), 668–675. http://doi.org/10.1016/j.clnu.2018.04.004

Binks, H., Vincent, G. E., Gupta, C., Irwin, C., & Khalesi, S. (2020). Effects of Diet on Sleep: A Narrative Review. Nutrients, 12(4), 936. http://doi.org/10.3390/nu12040936

Rao, T. P., Ozeki, M., & Juneja, L. R. (2015). In Search of a Safe Natural Sleep Aid. Journal of the American College of Nutrition, 34(5), 436–447. http://doi.org/10.1080/07315724.2014.926153

Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012 Dec;17(12):1161-9. https://pubmed.ncbi.nlm.nih.gov/23853635/

Aspy, D. J., Madden, N. A., & Delfabbro, P. (2018). Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep. Perceptual and Motor Skills, 003151251877032. http://doi.org/10.1177/0031512518770326

Parazzini F. Resveratrol, tryptophanum, glycine and vitamin E: a nutraceutical approach to sleep disturbance and irritability in peri- and post-menopause. Minerva Ginecol. 2015;67(1):1-5. https://pubmed.ncbi.nlm.nih.gov/25660429/

Siegel JM. The neurotransmitters of sleep. J Clin Psychiatry. 2004;65 Suppl 16:4-7. https://pubmed.ncbi.nlm.nih.gov/15575797/

Djeridane, Y., Touitou, Y. Chronic diazepam administration differentially affects melatonin synthesis in rat pineal and Harderian glands. Psychopharmacology154, 403–407 (2001). https://doi.org/10.1007/s002130000631

Betti L, Palego L, Demontis GC, Miraglia F, Giannaccini G. Hydroxyindole-O-methyltransferase (HIOMT) activity in the retina of melatonin-proficient mice. Heliyon. 2019;5(9):e02417. Published 2019 Sep 14. doi:10.1016/j.heliyon.2019.e02417

Haduch, A., Bromek, E., Wójcikowski, J., Gołembiowska, K., Daniel, W.. Melatonin Supports Serotonin Formation by Brain CYP2D. Drug Metabolism and DispositionMarch 1, 2016, 44 (3) 445-452; DOI: https://doi.org/10.1124/dmd.115.067413

Morton, D. J. (1987). Mechanism of Inhibition of Bovine Pineal Gland Hydroxyindole-O-Methyltransferase (EC 2.1.1.4) by Divalent Cations. Journal of Pineal Research, 4(3), 295–303. http://doi.org/10.1111/j.1600-079x.1987.tb00867.x

Markova-Car, E. P., Jurišić, D., Ilić, N., & Pavelić, S. K. (2014). Running for time: circadian rhythms and melanoma. Tumor Biology, 35(9), 8359–8368. http://doi.org/10.1007/s13277-014-1904-2

Slominski AT, Zmijewski MA, Skobowiat C, Zbytek B, Slominski RM, Steketee JD. Sensing the environment: regulation of local and global homeostasis by the skin’s neuroendocrine system. Adv Anat Embryol Cell Biol. 2012;212:v-115. doi:10.1007/978-3-642-19683-6_1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422784/

Chalupsky, K., Kračun, D., Kanchev, I., Bertram, K., & Görlach, A. (2015). Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase. Antioxidants & Redox Signaling, 23(14), 1076–1091. http://doi.org/10.1089/ars.2015.6329

Dianzani, I., Sanctis, L. D., Smooker, P. M., Gough, T. J., Alliaudi, C., Brusco, A., … Cotton, R. G. H. (1998). Dihydropteridine reductase deficiency: Physical structure of the QDPR gene, identification of two new mutations and genotype–phenotype correlations. Human Mutation, 12(4), 267–273. http://doi.org/10.1002/(sici)1098-1004(1998)12:4<267::aid-humu8>3.0.co;2-c

Nichol, C. A., Lee, C. L., Edelstein, M. P., Chao, J. Y., & Duch, D. S. (1983). Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo. Proceedings of the National Academy of Sciences, 80(6), 1546–1550. http://doi.org/10.1073/pnas.80.6.1546

Titus, F., Dávalos, A., Alom, J., & Codina, A. (1986). 5-Hydroxytryptophan versus Methysergide in the Prophylaxis of Migraine. European Neurology, 25(5), 327–329. http://doi.org/10.1159/000116030

Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998;3(4):271-280. https://pubmed.ncbi.nlm.nih.gov/9727088/

Volpi-Abadie J, Kaye AM, Kaye AD. Serotonin syndrome. Ochsner J. 2013;13(4):533-540. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865832/

Valadas, J. S., Esposito, G., Vandekerkhove, D., Miskiewicz, K., Deaulmerie, L., Raitano, S., … Verstreken, P. (2018). ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease. Neuron, 98(6). http://doi.org/10.1016/j.neuron.2018.05.022

Chung SY, Moriyama T, Uezu E, et al. Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia. J Nutr. 1995;125(6):1484-1489. doi:10.1093/jn/125.6.1484 https://pubmed.ncbi.nlm.nih.gov/7782901/

Montgomery, P., Burton, J. R., Sewell, R. P., Spreckelsen, T. F., & Richardson, A. J. (2014). Fatty acids and sleep in UK children: subjective and pilot objective sleep results from the DOLAB study – a randomized controlled trial. Journal of Sleep Research, 23(4), 364–388. http://doi.org/10.1111/jsr.12135

Alzoubi, K. H., Mayyas, F., & Zamzam, H. I. A. (2019). Omega-3 fatty acids protects against chronic sleep-deprivation induced memory impairment. Life Sciences, 227, 1–7. http://doi.org/10.1016/j.lfs.2019.04.028

Nasehi, M., Mosavi-Nezhad, S.-M., Khakpai, F., & Zarrindast, M.-R. (2018). The role of omega-3 on modulation of cognitive deficiency induced by REM sleep deprivation in rats. Behavioural Brain Research, 351, 152–160. http://doi.org/10.1016/j.bbr.2018.06.002

Jahangard, L., Sadeghi, A., Ahmadpanah, M., Holsboer-Trachsler, E., Bahmani, D. S., Haghighi, M., & Brand, S. (2018). Influence of adjuvant omega-3-polyunsaturated fatty acids on depression, sleep, and emotion regulation among outpatients with major depressive disorders – Results from a double-blind, randomized and placebo-controlled clinical trial. Journal of Psychiatric Research, 107, 48–56. http://doi.org/10.1016/j.jpsychires.2018.09.016

Scorza, F. A., Cavalheiro, E. A., Scorza, C. A., Galduróz, J. C. F., Tufik, S., & Andersen, M. L. (2013). Sleep Apnea and Inflammation – Getting a Good Night’s Sleep with Omega-3 Supplementation. Frontiers in Neurology, 4. http://doi.org/10.3389/fneur.2013.00193

Hansen, A. L., Dahl, L., Olson, G., Thornton, D., Graff, I. E., Frøyland, L., … Pallesen, S. (2014). Fish Consumption, Sleep, Daily Functioning, and Heart Rate Variability. Journal of Clinical Sleep Medicine, 10(05), 567–575. http://doi.org/10.5664/jcsm.3714

Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., … Nedergaard, M. (2013). Sleep Drives Metabolite Clearance from the Adult Brain. Science, 342(6156), 373–377. http://doi.org/10.1126/science.1241224

Varshavsky, A. (2012). Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis. Protein Science, 21(11), 1634–1661. http://doi.org/10.1002/pro.2148

Mackiewicz, M., Shockley, K. R., Romer, M. A., Galante, R. J., Zimmerman, J. E., Naidoo, N., … Pack, A. I. (2007). Macromolecule biosynthesis: a key function of sleep. Physiological Genomics, 31(3), 441–457. http://doi.org/10.1152/physiolgenomics.00275.2006

Scharf, M. T., Naidoo, N., Zimmerman, J. E., & Pack, A. I. (2008). The energy hypothesis of sleep revisited. Progress in Neurobiology, 86(3), 264–280. http://doi.org/10.1016/j.pneurobio.2008.08.003

Horne, J. (2009). REM sleep, energy balance and ‘optimal foraging.’ Neuroscience & Biobehavioral Reviews, 33(3), 466–474. http://doi.org/10.1016/j.neubiorev.2008.12.002

Berger, R. J., & Phillips, N. H. (1995). Energy conservation and sleep. Behavioural Brain Research, 69(1-2), 65–73. http://doi.org/10.1016/0166-4328(95)00002-b

Benington, J. H., & Heller, H. C. (1995). Restoration of brain energy metabolism as the function of sleep. Progress in Neurobiology, 45(4), 347–360. http://doi.org/10.1016/0301-0082(94)00057-o

Abel, T., Havekes, R., Saletin, J. M., & Walker, M. P. (2013). Sleep, Plasticity and Memory from Molecules to Whole-Brain Networks. Current Biology, 23(17). http://doi.org/10.1016/j.cub.2013.07.025

Rasch, B., & Born, J. (2013). About Sleeps Role in Memory. Physiological Reviews, 93(2), 681–766. http://doi.org/10.1152/physrev.00032.2012

Cirelli, C., & Tononi, G. (2008). Is Sleep Essential? PLoS Biology, 6(8). http://doi.org/10.1371/journal.pbio.0060216

Siegel, J. M. (2005). Clues to the functions of mammalian sleep. Nature, 437(7063), 1264–1271. http://doi.org/10.1038/nature04285

Campbell, S. S., & Tobler, I. (1984). Animal sleep: A review of sleep duration across phylogeny. Neuroscience & Biobehavioral Reviews, 8(3), 269–300. http://doi.org/10.1016/0149-7634(84)90054-x

Tobler, I. (1995). Is sleep fundamentally different between mammalian species? Behavioural Brain Research, 69(1-2), 35–41. http://doi.org/10.1016/0166-4328(95)00025-o

Tononi, G., & Cirelli, C. (2006). Sleep function and synaptic homeostasis. Sleep Medicine Reviews, 10(1), 49–62. http://doi.org/10.1016/j.smrv.2005.05.002

Dongen, H. P. A. V., Vitellaro, K. M., & Dinges, D. F. (2005). Individual Differences in Adult Human Sleep and Wakefulness: Leitmotif for a Research Agenda. Sleep, 28(4), 479–498. http://doi.org/10.1093/sleep/28.4.479

Vyazovskiy, V. V., & Delogu, A. (2014). NREM and REM Sleep. The Neuroscientist, 20(3), 203–219. http://doi.org/10.1177/1073858413518152

Mignot, E. (2008). Why We Sleep: The Temporal Organization of Recovery. PLoS Biology, 6(4). http://doi.org/10.1371/journal.pbio.0060106

Siegel, J. M. (2009). Sleep viewed as a state of adaptive inactivity. Nature Reviews Neuroscience, 10(10), 747–753. http://doi.org/10.1038/nrn2697

Horne, J. (2000). REM sleep — by default? Neuroscience & Biobehavioral Reviews, 24(8), 777–797. http://doi.org/10.1016/s0149-7634(00)00037-3

Baran, B., Pace-Schott, E. F., Ericson, C., & Spencer, R. M. C. (2012). Processing of Emotional Reactivity and Emotional Memory over Sleep. Journal of Neuroscience, 32(3), 1035–1042. http://doi.org/10.1523/jneurosci.2532-11.2012

Tononi, G., & Cirelli, C. (2014). Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration. Neuron, 81(1), 12–34. http://doi.org/10.1016/j.neuron.2013.12.025

Li, J., Vitiello, M. V., & Gooneratne, N. S. (2018). Sleep in Normal Aging. Sleep Medicine Clinics, 13(1), 1–11. http://doi.org/10.1016/j.jsmc.2017.09.001

Murillo-Rodriguez, E., Arias-Carrion, O., Zavala-Garcia, A., Sarro-Ramirez, A., & Huitron-Resendiz, S. (2012). Basic Sleep Mechanisms: An Integrative Review. Central Nervous System Agents in Medicinal Chemistry, 12(1), 38–54. http://doi.org/10.2174/187152412800229107

Weber, F. D. (2018). Sleep: Eye-Opener Highlights Sleep’s Organization. Current Biology, 28(5). http://doi.org/10.1016/j.cub.2018.01.054

Yetton, B. D., Mcdevitt, E. A., Cellini, N., Shelton, C., & Mednick, S. C. (2018). Quantifying sleep architecture dynamics and individual differences using big data and Bayesian networks. Plos One, 13(4). http://doi.org/10.1371/journal.pone.0194604

Colrain, I. M., Nicholas, C. L., & Baker, F. C. (2014). Alcohol and the sleeping brain. Handbook of Clinical Neurology Alcohol and the Nervous System, 415–431. http://doi.org/10.1016/b978-0-444-62619-6.00024-0

Zisapel, N. (2018). New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. British Journal of Pharmacology, 175(16), 3190–3199. http://doi.org/10.1111/bph.14116

Tosini, G., Baba, K., Hwang, C. K., & Iuvone, P. M. (2012). Melatonin: An underappreciated player in retinal physiology and pathophysiology. Experimental Eye Research, 103, 82–89. http://doi.org/10.1016/j.exer.2012.08.009

Blasiak, J., Reiter, R. J., & Kaarniranta, K. (2016). Melatonin in Retinal Physiology and Pathology: The Case of Age-Related Macular Degeneration. Oxidative Medicine and Cellular Longevity, 2016, 1–12. http://doi.org/10.1155/2016/6819736

Bellingham, J., Chaurasia, S. S., Melyan, Z., Liu, C., Cameron, M. A., Tarttelin, E. E., … Lucas, R. J. (2006). Evolution of Melanopsin Photoreceptors: Discovery and Characterization of a New Melanopsin in Nonmammalian Vertebrates. PLoS Biology, 4(8). http://doi.org/10.1371/journal.pbio.0040254

Zaidi, F. H., Hull, J. T., Peirson, S. N., Wulff, K., Aeschbach, D., Gooley, J. J., … Lockley, S. W. (2007). Short-Wavelength Light Sensitivity of Circadian, Pupillary, and Visual Awareness in Humans Lacking an Outer Retina. Current Biology, 17(24), 2122–2128. http://doi.org/10.1016/j.cub.2007.11.034

Legates, T. A., Altimus, C. M., Wang, H., Lee, H.-K., Yang, S., Zhao, H., … Hattar, S. (2012). Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature, 491(7425), 594–598. http://doi.org/10.1038/nature11673

Sikka, G., Hussmann, G. P., Pandey, D., Cao, S., Hori, D., Park, J. T., … Berkowitz, D. E. (2014). Melanopsin mediates light-dependent relaxation in blood vessels. Proceedings of the National Academy of Sciences, 111(50), 17977–17982. http://doi.org/10.1073/pnas.1420258111

Buhr, E. D., Yoo, S.-H., & Takahashi, J. S. (2010). Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators. Science, 330(6002), 379–385. http://doi.org/10.1126/science.1195262

Robbins, R., Grandner, M. A., Buxton, O. M., Hale, L., Buysse, D. J., Knutson, K. L., … Jean-Louis, G. (2019). Sleep myths: an expert-led study to identify false beliefs about sleep that impinge upon population sleep health practices. Sleep Health, 5(4), 409–417. http://doi.org/10.1016/j.sleh.2019.02.002

Damiola, F. (2000). Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes & Development, 14(23), 2950–2961. http://doi.org/10.1101/gad.183500

Abel, T., Havekes, R., Saletin, J. M., & Walker, M. P. (2013). Sleep, Plasticity and Memory from Molecules to Whole-Brain Networks. Current Biology, 23(17). http://doi.org/10.1016/j.cub.2013.07.025

Muzet, A., Ehrhart, J., Candas, V., Libert, J. P., & Vogt, J. J. (1983). Rem Sleep and Ambient Temperature in Man. International Journal of Neuroscience, 18(1-2), 117–125. http://doi.org/10.3109/00207458308985885

Saini, C., Morf, J., Stratmann, M., Gos, P., & Schibler, U. (2012). Simulated body temperature rhythms reveal the phase-shifting behavior and plasticity of mammalian circadian oscillators. Genes & Development, 26(6), 567–580. http://doi.org/10.1101/gad.183251.111

Franco P, Szliwowski H, Dramaix M, Kahn A. Influence of ambient temperature on sleep characteristics and autonomic nervous control in healthy infants. Sleep. 2000 May 1;23(3):401-7. https://pubmed.ncbi.nlm.nih.gov/10811384/

Libert JP, Candas V, Muzet A, Ehrhart J. Thermoregulatory adjustments to thermal transients during slow wave sleep and REM sleep in man. J Physiol (Paris). 1982;78(3):251-7 https://pubmed.ncbi.nlm.nih.gov/7166740/

Palca, J. W., Walker, J. M., & Berger, R. J. (1986). Thermoregulation, metabolism, and stages of sleep in cold-exposed men. Journal of Applied Physiology, 61(3), 940–947. http://doi.org/10.1152/jappl.1986.61.3.940

Lack. (2009). Chronotype differences in circadian rhythms of temperature, melatonin, and sleepiness as measured in a modified constant routine protocol. Nature and Science of Sleep, 1. http://doi.org/10.2147/nss.s6234

Samson, D. R., Crittenden, A. N., Mabulla, I. A., Mabulla, A. Z. P., & Nunn, C. L. (2017). Chronotype variation drives night-time sentinel-like behaviour in hunter–gatherers. Proceedings of the Royal Society B: Biological Sciences, 284(1858), 20170967. http://doi.org/10.1098/rspb.2017.0967

Walker, R. J., Kribs, Z. D., Christopher, A. N., Shewach, O. R., & Wieth, M. B. (2014). Age, the Big Five, and time-of-day preference: A mediational model. Personality and Individual Differences, 56, 170–174. http://doi.org/10.1016/j.paid.2013.09.003

Bjorness, T., & Greene, R. (2009). Adenosine and Sleep. Current Neuropharmacology, 7(3), 238–245. http://doi.org/10.2174/157015909789152182

Dworak, M., Diel, P., Voss, S., Hollmann, W., & Strüder, H. (2007). Intense exercise increases adenosine concentrations in rat brain: Implications for a homeostatic sleep drive. Neuroscience, 150(4), 789–795. http://doi.org/10.1016/j.neuroscience.2007.09.062

Rainnie, D., Grunze, H., Mccarley, R., & Greene, R. (1994). Adenosine inhibition of mesopontine cholinergic neurons: implications for EEG arousal. Science, 263(5147), 689–692. http://doi.org/10.1126/science.8303279

Daly, J. W., Shi, D., Nikodijevic, O., & Jacobson, K. A. (1994). The role of adenosine receptors in the central action of caffeine. Pharmacopsychoecologia, 7(2), 201–213. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373791/

Author

  • Paddy Farrell

    Hey, I'm Paddy!

    I am a coach who loves to help people master their health and fitness. I am a personal trainer, strength and conditioning coach, and I have a degree in Biochemistry and Biomolecular Science. I have been coaching people for over 10 years now.

    When I grew up, you couldn't find great health and fitness information, and you still can't really. So my content aims to solve that!

    I enjoy training in the gym, doing martial arts, hiking in the mountains (around Europe, mainly), drawing and coding. I am also an avid reader of philosophy, history, and science. When I am not in the mountains, exercising or reading, you will likely find me in a museum.

    View all posts