Drug Use Disorders in Latin America & Caribbean

This page presents drug use disorders mortality data for countries in Latin America & Caribbean, using age-standardized death rates per 100,000 population from the Institute for Health Metrics and Evaluation (IHME). Regional analysis reveals significant variation in disease burden between countries, reflecting differences in healthcare infrastructure, socioeconomic conditions, environmental risk factors, and public health policy implementation across Latin America & Caribbean.

Drug use disorders — encompassing opioid, stimulant, cannabis, and other substance use disorders — directly cause approximately 170,000 deaths per year, with opioid overdose accounting for roughly three-quarters of drug death mortality. The opioid crisis in North America has been particularly devastating, with synthetic opioids (fentanyl and its analogues) driving record overdose deaths exceeding 100,000 per year in the United States alone. Globally, an estimated 296 million people used drugs in 2021. Injecting drug use is a major driver of HIV and hepatitis C transmission. While North America and Europe bear the highest absolute burden of drug overdose deaths, methamphetamine use is a growing concern in East and Southeast Asia, and tramadol misuse is rising in West Africa. Drug use disorders are chronic relapsing conditions influenced by genetic vulnerability, childhood adversity, mental health comorbidities, social environment, and drug availability. Criminalisation and stigma impede access to treatment and harm reduction in many settings. Latin America and the Caribbean have made substantial gains in life expectancy over recent decades, but face growing non-communicable disease burdens, persistent health inequalities, and pockets of high violence-related mortality. In Latin America & Caribbean, drug use disorders mortality is broadly consistent with global patterns, though wide disparities exist between upper-middle-income countries and lower-income Caribbean and Central American nations.

Harm reduction — needle and syringe programmes, opioid agonist therapy (methadone, buprenorphine), naloxone distribution for overdose reversal, and supervised consumption facilities — saves lives and reduces HIV and hepatitis transmission. Evidence-based addiction treatment includes medication-assisted treatment, cognitive-behavioural therapy, and contingency management. Prescription drug monitoring programmes and opioid prescribing guidelines aim to prevent iatrogenic addiction. Addressing social determinants — housing, employment, mental health services — is essential for sustained recovery.

The mortality estimates presented on this page are derived from the Global Burden of Disease (GBD) study, produced by the Institute for Health Metrics and Evaluation (IHME). The GBD synthesizes data from vital registration systems, verbal autopsies, cancer registries, and surveillance networks across more than 200 countries and territories. Death rates are expressed per 100,000 population and are age-standardized, which adjusts for differences in age structure between populations so that comparisons across countries and over time reflect genuine differences in mortality risk rather than demographic composition.

The dataset typically covers the period from 1990 to 2023, although availability varies by country and cause. When interpreting the figures for drug use disorders in Latin America & Caribbean, note that higher age-standardized rates indicate a greater mortality burden independent of whether a country's population is older or younger. Trends over time reveal whether public health interventions, economic development, and health system improvements have reduced or increased the toll of this condition in the region.

Disease-specific death rates measure the number of deaths directly attributed to drug use disorders per 100,000 people, after accounting for age structure. These rates capture both the prevalence of the condition and the likelihood of a fatal outcome once affected. In Latin America & Caribbean, variation across countries may reflect differences in disease prevalence, access to treatment, diagnostic capacity, and the presence of comorbidities. Examining trends alongside health expenditure and intervention coverage helps identify where policy action has been most effective.

Drug Use Disorders Worldwide All Causes in Latin America & Caribbean Compare Countries Trends Drug Use Disorders in East Asia & Pacific Drug Use Disorders in Europe & Central Asia Drug Use Disorders in Middle East, North Africa, Afghanistan & Pakistan Drug Use Disorders in North America